Aim: The aim of this study is to examine the protective properties of and against the development of skin cancer.
Methods: The skin cancer balb/c mouse model was utilized in the study. Plant extracts were administered to animals using oral gavage. In addition, skin cancer was induced using 7,12-dimethylbenz( a) anthracene (DMBA).
Results: The study found that extract reduced both tumor incidence (P<0.01) and papilloma frequency (<0.001) and delayed the onset of tumor development (<0.001). The extract did not affect tumor size in animals. leaf extract reduced the number of tumors per animal, the incidence of tumors, and the frequency of papilloma (<0.05). In addition, it delayed (<0.01) the onset of tumors. Treatment of animals with seed extract reduced the frequency of papilloma (P<0.05) and delayed the onset of tumors (<0.05). However, the examined plant extracts did not impact the size of tumors induced by DMBA (>0.05).
Conclusion: The findings of this study revealed that and could protect against cancer development as indicated using the animal model of skin painting assay.
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| http://dx.doi.org/10.2174/1568009623666230817101757 | DOI Listing |
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