AI Article Synopsis

  • Researchers studied multiple myeloma, a type of blood cancer, to understand how it behaves differently in various parts of the body.
  • They found that patients had an average of 6 different tumor types and noticed some unique types in certain spots.
  • The study showed that tumor cells can act differently in different locations, which could affect how doctors plan treatments like immunotherapy.

Article Abstract

In multiple myeloma spatial differences in the subclonal architecture, molecular signatures and composition of the microenvironment remain poorly characterized. To address this shortcoming, we perform multi-region sequencing on paired random bone marrow and focal lesion samples from 17 newly diagnosed patients. Using single-cell RNA- and ATAC-seq we find a median of 6 tumor subclones per patient and unique subclones in focal lesions. Genetically identical subclones display different levels of spatial transcriptional plasticity, including nearly identical profiles and pronounced heterogeneity at different sites, which can include differential expression of immunotherapy targets, such as CD20 and CD38. Macrophages are significantly depleted in the microenvironment of focal lesions. We observe proportional changes in the T-cell repertoire but no site-specific expansion of T-cell clones in intramedullary lesions. In conclusion, our results demonstrate the relevance of considering spatial heterogeneity in multiple myeloma with potential implications for models of cell-cell interactions and disease progression.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435504PMC
http://dx.doi.org/10.1038/s41467-023-40584-4DOI Listing

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