Objective: To update the evidence in relation to the use of dialkylcarbamoyl chloride (DACC)-coated wound dressings in the prevention, treatment and management of wounds.
Method: PubMed and PubMed Central databases were searched to identify articles published since 2020 describing the experimental and clinical evidence for DACC-coated dressings, and their antimicrobial effect, as well as their impact on the prevention and treatment of infected wounds. The identified articles were then narratively reviewed.
Results: The search yielded 113 articles (plus references from ad hoc sources), of which nine met the inclusion criteria. Of the nine included studies, five related to clinical aspects and four were laboratory studies.
Conclusion: A number of new studies have provided further evidence for the mode of action of the antimicrobial effect of DACC-coated dressings and its wide spectrum effect (including World Health Organization-prioritised microorganisms). Additional clinical studies have provided evidence of new applications, such as in treating wounds in paediatric patients, and extended the evidence relating to their use in treating surgical site infections. Evidence also shows that DACC-coated wound dressings can aid in the binding of biofilms, and how this technology can align and support antimicrobial stewardship in the prevention of antimicrobial resistance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.12968/jowc.2023.32.Sup8a.S13 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Does the use of DACC-coated dressings improve clinical outcomes for hard to heal wounds: A systematic review.
Int Wound J
October 2024
Wound Care Research and Development, Mölnlycke Health Care AB, Gothenburg, Sweden.
Article Synopsis
- - Reports of antimicrobial resistance have led some clinicians to use alternative wound dressings called DACC-coated dressings, claiming antimicrobial activity despite being non-medicated.
- - A systematic review was conducted to evaluate the effectiveness of these dressings on chronic wound healing and infection control, using the GRADE framework and PICO format to structure the research.
- - The review analyzed 748 records, ultimately including 10 relevant studies, but found the overall quality of evidence to be very low, highlighting the need for more rigorous randomized controlled trials for better clarity on DACC-coated dressings.
Experimental and clinical evidence for DACC-coated dressings: an update.
J Wound Care
August 2023
Visiting Professor, Birmingham City University, Birmingham, UK.
Objective: To update the evidence in relation to the use of dialkylcarbamoyl chloride (DACC)-coated wound dressings in the prevention, treatment and management of wounds.
Method: PubMed and PubMed Central databases were searched to identify articles published since 2020 describing the experimental and clinical evidence for DACC-coated dressings, and their antimicrobial effect, as well as their impact on the prevention and treatment of infected wounds. The identified articles were then narratively reviewed.
Dressings and topical agents for the management of open wounds after surgical treatment for sacrococcygeal pilonidal sinus.
Cochrane Database Syst Rev
May 2022
Division of Health Sciences, School of Medicine, University of Nottingham, Derby, UK.
Background: Sacrococcygeal pilonidal sinus disease is a common debilitating condition that predominantly affects young adults, with a profound impact on their activities of daily living. The condition is treated surgically, and in some cases the wound in the natal cleft is left open to heal by itself. Many dressings and topical agents are available to aid healing of these wounds.
View Article and Find Full Text PDFBackground: Antimicrobial resistance (AMR) is one of the most serious health threats globally. The development of new antimicrobials is not keeping pace with the evolution of resistant microorganisms, and novel ways of tackling this problem are required. One of such initiatives has been the development of antimicrobial stewardship programmes (AMS).
View Article and Find Full Text PDFAntimicrobial stewardship strategies in wound care: evidence to support the use of dialkylcarbamoyl chloride (DACC)- coated wound dressings.
J Wound Care
April 2021
WoundCareSol Consultancy, UK.
Background: Traditionally, infections are treated with antimicrobials (for example, antibiotics, antiseptics, etc), but antimicrobial resistance (AMR) has become one of the most serious health threats of the 21st century (before the emergence of COVID-19). Wounds can be a source of infection by allowing unconstrained entry of microorganisms into the body, including antimicrobial-resistant bacteria. The development of new antimicrobials (particularly antibiotics) is not keeping pace with the evolution of resistant microorganisms and novel ways of addressing this problem are urgently required.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!