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Unlocking the Gates: A Novel Diagnostic Molecule for Quantifying Efflux Levels in Gram-Positive Bacteria.
Adv Healthc Mater
March 2025
Aix Marseille Université, INSERM, SSA, MCT, Marseille, 13385, France.
Efflux-mediated antibiotic resistance poses a significant global threat, affecting diverse bacterial species. Clinicians recognize the danger of efflux mechanisms during antibiotic treatment, yet precise diagnostic tools remain unavailable. The antibiogram currently infers abnormal efflux pump activity in clinical isolates, which is subsequently confirmed through transcriptomic or genomic analysis.
View Article and Find Full Text PDFPlasmodium falciparum histidine-rich protein 2/3 gene deletions and repeat motifs in Chhattisgarh, India (2017-2018).
Trans R Soc Trop Med Hyg
March 2025
Molecular Epidemiology department, ICMR-National Institute of Malaria Research, Sector 8, Dwarka, 110077 New Delhi, India.
Background: Rapid diagnostic tests (RDTs) are vital for malaria diagnosis, especially in resource-limited areas. RDTs targeting histidine-rich protein 2 (PfHRP2) and its structural homologue PfHRP3 are commonly used for detecting Plasmodium falciparum. However, genetic deletions in these proteins can affect test accuracy.
View Article and Find Full Text PDFIndirect ELISA-based detection of histatin 3 and cystatin D for the forensic identification of human saliva.
Anal Methods
March 2025
Department of Forensic Dentistry, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Analyzing forensically relevant body fluids contributes to proving criminal acts, and saliva is often left on the scene, especially in sexual assault cases. Currently, saliva is presumptively identified using its salivary α-amylase activity as an indicator. However, the specificity of saliva presumptive tests is low, and therefore, they cannot confidently prove the presence of saliva.
View Article and Find Full Text PDFRobotic animals as new tools in rodent neuroscience research: proposed applications of zooinspired robots for mouse behavioral testing.
Front Behav Neurosci
February 2025
Institute of Experimental Neurology (INSPE), Division of Neuroscience (DNS), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Bioinspired robots are machines which reproduce structural or functional features of a living organism. In particular, the bioinspired robots which reproduce features of animals can be more specifically defined as zooinspired robots. Currently, the applications of animal robots are various and range across different fields, such as, for instance, nature conservation, search and rescue of humans after natural or man-made disasters, exploration of extraterrestrial environments and robotic pets for elderly people under care for dementia.
View Article and Find Full Text PDFModeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?
Front Cardiovasc Med
February 2025
Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, CT, United States.
Thoracic aortic aneurysm and dissection (TAAD) significantly impact cardiovascular morbidity and mortality. A large subset of TAAD cases, particularly those with an earlier onset, is linked to heritable genetic defects. Despite progress in characterizing genes associated with both syndromic and non-syndromic heritable TAAD, the causative gene remains unknown in most cases.
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