Objective: This article provides an overview of the current definitions, diagnostic tools, and overall management of insomnia.
Latest Developments: The treatment of insomnia has shifted over time, with a growing emphasis on nonpharmacologic therapies as a first-line intervention and the leveraging of technology to aid in the dissemination of these therapies. With this evolution, the definition of insomnia has changed to reflect a common treatment pathway. As pharmacologic treatment options have increased, so has concern about the dangerous short-term and long-term adverse effects of these treatment options.
Essential Points: Insomnia is a common disorder, frequently overlapping with other neurologic and psychiatric disorders, which can cause significant distress and disruption to patients' lives. Nonpharmacologic therapies are highly effective and are now considered first-line treatments. Although efficacy is variable, numerous pharmacologic interventions are available, and many options come with considerable concern about adverse effects, particularly in populations over 65 years old.
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http://dx.doi.org/10.1212/CON.0000000000001283 | DOI Listing |
J Psychiatr Res
March 2025
School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan; Department of Nursing, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan. Electronic address:
Objective: In this pilot study, we investigated the effects of bright light therapy on depression in schizophrenia using a quasi-experimental design involving random assignment.
Methods: We included patients with schizophrenia who had stable psychiatric symptoms. Experimental group (n = 16) received light therapy while control group (n = 12) received only regular indoor light.
Ann Behav Med
January 2025
Department of Health Sciences, Section of Nursing Science, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Background: Fatigue is a prevalent and debilitating symptom among kidney transplant candidates (KTCs), significantly affecting their quality of life and overall well-being. Its complexity necessitates a comprehensive approach to manage fatigue in this population.
Purpose: To explore the effectiveness of nonpharmacological interventions in reducing fatigue in KTCs.
J Evid Based Med
March 2025
Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Objective: To identify and map systematic reviews on the effectiveness of treatment for depressive disorders among adults.
Methods: We retrieved systematic reviews and meta-analyses of randomized controlled trials involving adults with depressive symptoms from twelve English and four Chinese databases (June 21, 2022). Using an interactive map, we visualized the effectiveness of evidence on depression based on an intervention-outcome framework.
Ann Med
December 2025
Ministry of Health, Qassim Health Cluster, King Saud Hospital, Unayzah, Kingdom of Saudi Arabia.
Background/purpose: Atypical facial pain (AFP) is a chronic condition characterized by persistent facial pain without clear clinical signs, making diagnosis and treatment difficult. Common pharmacological treatments include antidepressants, anticonvulsants and neuromodulators, but their effectiveness remains uncertain, necessitating a systematic review to guide clinical practice.
Materials And Methods: Following PRISMA 2020 guidelines, randomized controlled trials (RCTs) evaluating pharmacological treatments for AFP in adults were included.
Explor Neurosci
February 2025
Department of Electrical and Computer Engineering, Purdue University, Indianapolis, IN 46202, USA.
The use of neurostimulation devices for the treatment of Alzheimer's disease (AD) is a growing field. In this review, we examine the mechanism of action and therapeutic indications of these neurostimulation devices in the AD process. Rapid advancements in neurostimulation technologies are providing non-pharmacological relief to patients affected by AD pathology.
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