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Polarity-Sensitive fluorescent probes based on triphenylamine for fluorescence lifetime imaging of lipid droplets.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, PR China. Electronic address:
Non-alcoholic fatty liver disease (NAFLD) is a disease closely associated with metabolic abnormalities. Lipid droplets (LDs) serve as organelles that store intracellular neutral lipids and maintain cellular energy homeostasis. Their abnormalities can cause metabolic disorders and disease, which is also one of the distinctive characteristics of NAFLD patients.
View Article and Find Full Text PDFGlia detect and transiently protect against dendrite substructure disruption in C. elegans.
Nat Commun
January 2025
Laboratory of Developmental Genetics, The Rockefeller University, New York, NY, USA.
Article Synopsis
- Glia are capable of monitoring dendrite substructures, similar to their role in assessing axon structures for myelination and repair.
- Disruption of dendrite cilia in C. elegans induces a rapid glial response that leads to increased protective extracellular matrix and changes in gene expression.
- The interactions between specific proteins (DGS-1 and FIG-1) in glial cells are crucial for detecting cilia integrity and support the glial protective response against dendrite damage.
New tools to monitor infection and biofilms in .
Front Cell Infect Microbiol
December 2024
School of Biosciences, University of Kent, Canterbury, United Kingdom.
Introduction: Antimicrobial resistance is a growing health problem. Pseudomonas aeruginosa is a pathogen of major concern because of its multidrug resistance and global threat, especially in health-care settings. The pathogenesis and drug resistance of depends on its ability to form biofilms, making infections chronic and untreatable as the biofilm protects against antibiotics and host immunity.
View Article and Find Full Text PDFProton Tunneling Allows a Proton-Coupled Electron Transfer Process in the Cancer Cell.
JACS Au
December 2024
Department of Chemistry, University of Antwerp, Antwerp 2020, Belgium.
Proton-coupled electron transfer (PCET) is a fundamental redox process and has clear advantages in selectively activating challenging C-H bonds in many biological processes. Intrigued by this activation process, we aimed to develop a facile PCET process in cancer cells by modulating proton tunneling. This approach should lead to the design of an alternative photodynamic therapy (PDT) that depletes the mitochondrial electron transport chain (ETC), the key redox regulator in cancer cells under hypoxia.
View Article and Find Full Text PDFToxicity assessment of wastewater treatment plant sludge using .
J Biosci
December 2024
Ecotoxicology Laboratory, Environmental Toxicology Group, FEST Division, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, India.
Globally, sewage sludge is produced in large quantities as a by-product in wastewater treatment plants (WWTPs), which have organic and inorganic contaminants. Due to its high caloric value, this sludge is used as manure in agricultural fields. For this, regular sludge monitoring is necessary to understand the potential risks and limit the release of toxic substances into the environment.
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