Feature-based molecular networking analysis suggested the presence of naphthol tetramers in 047219, the same species but a different strain from one used previously for the discovery of naphthol trimers promoting adiponectin synthesis. The new tetramers were composed of 5-methoxy-4-naphthol, each of which was connected to one another in various positions. Targeted isolation afforded six previously unreported naphthol tetramers (-) together with 13 known polyketides (-) including naphthol monomers, dimers, and trimers. Structures of the isolated compounds were established by using NMR and mass spectroscopic analysis. Nodulisporin A (), nodulisporin B (), and 1,1',3',3″-ternaphthalene-5,5',5″-trimethoxy-4,4',4″-triol () demonstrated anti-inflammatory activities against NO production, but the new compounds were less active.
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Discovery of Naphthol Tetramers from Endolichenic Fungus 047219 Based on MS/MS Molecular Networking.
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Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Feature-based molecular networking analysis suggested the presence of naphthol tetramers in 047219, the same species but a different strain from one used previously for the discovery of naphthol trimers promoting adiponectin synthesis. The new tetramers were composed of 5-methoxy-4-naphthol, each of which was connected to one another in various positions. Targeted isolation afforded six previously unreported naphthol tetramers (-) together with 13 known polyketides (-) including naphthol monomers, dimers, and trimers.
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