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| http://dx.doi.org/10.21037/tcr-23-716 | DOI Listing |
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Development and preliminary validation of five miRNAs for lung adenocarcinoma prognostic model associated with immune infiltration.
Sci Rep
January 2025
Department of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Our aim was to investigate the potential value of immune-related miRNA signaling in predicting clinical prognosis and immunotherapy. We first identified immune-related miRNAs in lung adenocarcinoma (LUAD), and then constructed a miRNA-based risk model by lasso regression modeling. Finally, we validated our findings using RT-qPCR in serum from LUAD patients and normal patients.
View Article and Find Full Text PDFUpregulation of LncRNAs G2E3-AS1 and BACE1-AS as Prognostic Biomarkers in Metastatic Colorectal Cancer.
Biomarkers
January 2025
Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Background: Despite the current diagnostic techniques and therapeutic methods for colorectal cancer (CRC), patients are often diagnosed at advanced stages of colorectal cancer with poor prognosis and distant metastasis. Recently, numerous investigations have highlighted the crucial role of lncRNAs in cancer development, progression, invasion, and metastasis. This study investigated less well-characterized genes in the colorectal cancer metastasis process using bioinformatics analysis and their confirmation by experimental methods.
View Article and Find Full Text PDF[Expression and Clinical Significance of in Multiple Myeloma Cells].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Hematology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, Anhui Province, China.
Objective: To investigate the expression of in newly diagnosed multiple myeloma (MM) and its correlation with clinical features and prognosis.
Methods: 115 MM patients diagnosed and treated in the Department of Hematology, the First Affiliated Hospital of Bengbu Medical University from January 2013 to January 2017 and 115 non-tumor controls were enrolled in this study. Clinical characteristics, pathological data and therapeutic responses of the patients were collected.
Breast cancer is the leading cause of death and morbidity among women. A major challenge for clinical management of breast cancer is the dissemination of breast cancer cells from the primary tumor site via lymphatic drainage, resulting in metastatic tumor spread. Recent studies have found that high expression of the microRNA miR-146a-5p is associated with better survival outcomes for breast cancer patients.
View Article and Find Full Text PDFBioinformatics-Based Construction of Immune-Related microRNA and mRNA Prognostic Models for Hepatocellular Carcinoma.
Cancer Manag Res
December 2024
Department of Oncology, Nantong First People's Hospital and Second Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, 226000, People's Republic of China.
Introduction: The development and progression of Hepatocellular Carcinoma (HCC) is more relevant to immune regulation. Therefore, there is an urgent need to find immune-related molecular markers that can predict the prognosis and immune status of HCC.
Methods: RNA-seq and clinical HCC data from the Cancer Genome Atlas (TCGA) were analyzed for differential expression of microRNA (miRNAs), mRNAs, and lncRNAs.
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