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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425928 | PMC |
| http://dx.doi.org/10.2478/jccm-2023-0019 | DOI Listing |
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Application of clinician support tools to improve wound healing outcomes and simplify treatment selection for effective exudate management.
Wounds
December 2024
Smith+Nephew, Watford, Hertfordshire, UK.
Background: Achievement of moisture balance can be a critical factor affecting time to closure of nonhealing wounds, and dry wounds can take much longer to heal than those with high exudate levels. Whether the goal of management is to donate moisture to the wound or control excessive fluid until the cause has been identified and addressed, choice of dressing and other wound management products can affect nursing resources, clinical outcomes, concordance, and quality of life for the patient.
Case Reports: The cases discussed illustrate differences in management approaches for dry and wet wounds and show how clinician support tools (eg, tissue type, infection/inflammation, moisture imbalance, epithelial edge advancement [TIME] clinical decision support tool) can facilitate treatment decisions.
Background: With the approval of several anti-amyloid antibodies and a robust pipeline of new amyloid-based therapies, attention turns towards questions related to real-world clinical practice. Here we explore the impact of several biological pathways on the amyloid biomarker response of AD patients using a Quantitative Systems Pharmacology (QSP) approach with the ultimate objective to find measurable biomarkers for responder identification.
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Background: The Centiloid method (CL) was introduced as a tracer-independent measure for cortical amyloid load and is now commonly used in Alzheimer's disease (AD) clinical trials. To facilitate its implementation into clinical settings, the AMYPAD consortium set out to integrate existing literature and recent work from the consortium to provide clinical context-of-use recommendations of the Centiloid scale, which has been submitted to the European Medicine Agency for endorsement as a Biomarker Qualification Opinion.
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Biomarkers.
Alzheimers Dement
December 2024
Institute for Neurodegenerative Diseases (IND) Florida, Boca Raton, FL, USA.
Background: Alzheimer's disease (AD), Dementia with Lewy Bodies (DLB), and other neurodegenerative diseases (NDD) develop over an extended preclinical period, sharing common risk factors and underlying pathophysiological mechanisms. Plasma proteins, including Amyloid-beta peptides (Aβ) and Tau isoforms, facilitate differential diagnosis of NDD in their earliest stages, allowing for timely delivery of targeted interventions. Blood-based biomarkers may also serve as a reliable means of monitoring disease progression and evaluating the effectiveness of individualized interventions across the spectrum of disease.
View Article and Find Full Text PDFBackground: A lesson of the recent progress in Alzheimer's Disease therapy is that biomarker-driven trials will be crucial to demonstrating efficacy in the clinic. Many studies have demonstrated the potential predictive power of fluid and imaging biomarkers in guiding patient selection and continued progress of precision medicine approaches will demand development of multi-dimensional biomarker arrays. However, correlations between candidate biomarkers change non-linearly with time, requiring methodologies to align biomarkers across a common disease timescale (time from amyloid positivity; TFAP).
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