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Sertraline in depressed patients with or at risk for coronary heart disese: a systemic review.
Am J Cardiovasc Dis
December 2024
Otorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Amiralmomenin Hospital, Guilan University of Medical Sciences Rasht, Iran.
Background And Aims: Depression is a prevalent comorbidity among patients with coronary heart disease (CHD). While recent studies have hinted at a possible association between CHD and antidepressant medications like sertraline, the existing evidence remains inconclusive. To investigate this potential link, we conducted a comprehensive systematic review.
View Article and Find Full Text PDFDeveloping a translational research framework for MDD: combining biomolecular mechanisms with a spiraling risk factor model.
Front Psychiatry
January 2025
Department of Pharmaceutical Sciences and Freudenthal Institute, Utrecht University, Utrecht, Netherlands.
Objective: The global incidence and burden of Major Depressive Disorder (MDD) are increasing annually, with current antidepressant treatments proving ineffective for 30-40% of patients. Biomolecular mechanisms within the microbiota-gut-brain axis (MGBA) may significantly contribute to MDD, potentially paving the way for novel treatment approaches. However, integrating the MGBA with the psychological and environmental aspects of MDD remains challenging.
View Article and Find Full Text PDFData-driven discovery of associations between prescribed drugs and dementia risk: A systematic review.
Alzheimers Dement (N Y)
January 2025
Department of Health and Community Sciences, Medical School University of Exeter Exeter UK.
Abstract: Recent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whether existing medications for other conditions may affect dementia risk. We conducted a systematic review to identify studies adopting a data-driven approach to investigate the association between a wide range of prescribed medications and dementia risk.
View Article and Find Full Text PDFDoes Concomitant Use of Antidepressants and Direct Oral Anticoagulants Increase the Risk of Bleeding?: A Systematic Review and Meta-Analysis.
J Clin Psychopharmacol
January 2025
Department of Pharmacy, Lishui City Maternal and Child Health Care Hospital, Lishui City, Zhejiang Province, China.
Purpose: To evaluate the risk of bleeding associated with the simultaneous administration of antidepressants (ADs) and direct oral anticoagulants (DOACs).
Methods: PubMed, Embase, and Scopus databases were searched for papers that focused on the concomitant administration of ADs and DOACs and presented data on the bleeding outcomes. The comparator group of interest consisted of subjects who received only DOACs.
A real-world analysis of antidepressant medications in US veterans aged 60 years and older: a comparative analysis.
J Comp Eff Res
January 2025
Dorn Research Institute, Columbia VA Health Care System, Columbia, SC, USA.
To compare the safety and efficacy of antidepressants (AD) among older adults with major depressive disorder (MDD) by assessing treatment change, augmentation and hospitalization rates. This retrospective study analyzed data from the Veterans Affairs (VA) database, including 142,138 patients aged ≥60 years diagnosed with MDD. Patients prescribed bupropion, citalopram, duloxetine, escitalopram, fluoxetine, mirtazapine, paroxetine, sertraline, or venlafaxine were included.
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