Background: The opioid crisis continues in full force, as physicians and caregivers are desperate for resources to help patients with opioid use and chronic pain disorders find safer and more accessible non-opioid tools.
Main Body: The purpose of this article is to review the current state of the opioid epidemic; the shifting picture of cannabinoids; and the research, policy, and current events that make opioid risk reduction an urgent public health challenge. The provided table contains an evidence-based clinical framework for the utilization of cannabinoids to treat patients with chronic pain who are dependent on opioids, seeking alternatives to opioids, and tapering opioids.
Conclusion: Based on a comprehensive review of the literature and epidemiological evidence to date, cannabinoids stand to be one of the most interesting, safe, and accessible tools available to attenuate the devastation resulting from the misuse and abuse of opioid narcotics. Considering the urgency of the opioid epidemic and broadening of cannabinoid accessibility amidst absent prescribing guidelines, the authors recommend use of this clinical framework in the contexts of both clinical research continuity and patient care.
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http://dx.doi.org/10.1186/s12954-023-00842-6 | DOI Listing |
Eur J Nucl Med Mol Imaging
December 2024
Department of Nuclear Medicine, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, Sichuan, 610041, China.
Purpose: Extranodal natural killer/T-cell lymphoma (ENKTCL) is an hematologic malignancy with prognostic heterogeneity. We aimed to develop and validate DeepENKTCL, an interpretable deep learning prediction system for prognosis risk stratification in ENKTCL.
Methods: A total of 562 patients from four centers were divided into the training cohort, validation cohort and test cohort.
Discov Oncol
December 2024
Department of Critical Care Medicine, The Fifth People's Hospital of Ganzhou City, Ganzhou, 341000, China.
Lung adenocarcinoma (LUAD) is a major contributor to cancer-related deaths, distinguished by its pronounced tumor heterogeneity and persistent challenges in overcoming drug resistance. In this study, we utilized single-cell RNA sequencing (scRNA-seq) to dissect the roles of programmed cell death (PCD) pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis, in shaping LUAD heterogeneity, immune infiltration, and prognosis. Among these, ferroptosis and pyroptosis were most significantly associated with favorable survival outcomes, highlighting their potential roles in enhancing anti-tumor immunity.
View Article and Find Full Text PDFJ Geriatr Phys Ther
December 2024
School of Psychology and Public Health, La Trobe University, Victoria, Australia.
Background And Purpose: Motivational interviewing, an evidence-based person-centered counseling style, may help to facilitate increased mobility and physical activity after hip fracture. We explored contextual factors influencing the outcome, mechanism, and implementation of motivational interviewing after hip fracture.
Methods: A qualitative study was completed using an interpretive description framework.
J Vis Exp
December 2024
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences; Department of Psychology, University of Chinese Academy of Sciences;
The Acute Stress Disorder Scale (ASDS) is crucial for assessing acute stress disorder (ASD), especially in high-stress environments like Intensive Care Units (ICUs). Traditional methods struggle to interpret all 19 ASDS variables simultaneously. This study introduces a novel polar histogram visualization approach to enhance ASDS score analysis, focusing on elderly ICU caregivers.
View Article and Find Full Text PDFJ Gerontol A Biol Sci Med Sci
December 2024
Department of Scientific Research, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No.1, Dahua Road, Dongdan, Dongcheng District, Beijing, 100730, P. R. China.
Background: Intrinsic capacity (IC), as a potential proxy for healthy ageing, guidance on framing the concept is limited. Furthermore, research on the relationship between IC and catastrophic health expenditure (CHE) is scarce.The current study aims to construct a validated IC framework using structural equation modelling (SEM) and examine such an association among older adults in China.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!