AI Article Synopsis
- Botulism is a rare but serious disease in the Czech Republic, with only 155 cases reported since 1960 and just three isolated cases since 2013, aside from one familial instance.
- In July 2022, a couple developed botulism after consuming an untraceable pâté and exhibited neurological symptoms, particularly dysarthria.
- Their condition improved significantly after treatment with antibotulinum serum, and modern techniques like MALDI mass spectrometry were used for diagnosis, avoiding the need for traditional animal testing.
Article Abstract
In the Czech Republic, botulism is a rare life-threatening disease. A total of 155 cases have been reported since 1960; according to the ISIN (formerly EPIDAT) database, there have been only three isolated cases since 2013, with the exception of a single occurrence of familial botulism in 2013. In our work, we present the occurrence of botulism after ingestion of pâté of untraceable origin by a couple who were hospitalized for botulotoxin food poisoning in July 2022. Their neurological symptoms were dominated by dysarthria. After administration of antibotulinum serum, their condition improved significantly. Patient samples were analyzed using affinity carriers and MALDI mass spectrometry, a modern highly sensitive technique for detecting the presence of botulinum neurotoxins. Unlike traditional detection by a difficult and costly biological experiment on mice, the above analysis does not require the killing of laboratory animals.
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