AI Article Synopsis
- A new cyclic natural compound, formed from succinic acid and two alanine amino acid units, was isolated from honey extract and its structure was determined through various NMR techniques.
- In cell culture studies, this compound reduced the number of tachyzoites (a parasitic stage) by 40-56% within 24 hours, and 25-50% over 72 hours, in a dose-dependent manner.
- The compound showed no toxicity to glial cells at concentrations up to 25 µg/mL and was associated with increased nitric oxide levels, suggesting a potential impact on DNA synthesis and protein production in affected cells.
Article Abstract
A new cyclic natural compound formed by succinic acid and two alanine amino acid units was isolated from the honey extract. The chemical structure of was established based on spectroscopic data analysis, including one- (H and C NMR) and two-dimensional NMR techniques (H-H-COSY, HSQC and HMBC). A primary culture model previously infected with was used to evaluate for two time intervals (24 and 72 h), showing a reduction (40-56%) of the number of tachyzoites in the first 24 h and until 72 h, a dose-dependent reduction in parasite proliferation (25-50%). Glial cells treated with did not demonstrate toxicity at concentrations up to 25 ug/mL. Treated and infected cultures showed an increase in NO when compared to control cells in 24 h and 72 h. studies suggest that the new compound may affect DNA synthesis and impair -protein production.
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| http://dx.doi.org/10.1080/14786419.2023.2245538 | DOI Listing |
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