AI Article Synopsis
- The paper outlines a non-invasive method for measuring how radioactively tagged tracer particles clear from the alveolar region in rabbit lungs.
- It discusses the validation of this method and presents findings on the clearance of 3.5-micron latex particles observed over a 56-day period.
- The results indicate two clearance phases for alveolar latex particles, with half-times of 4.9 days and 30.1 days, while particles deposited in the tracheobronchial tree clear within 2 days.
Article Abstract
This paper describes a method for the measurement of the clearance of inert, insoluble radioactively tagged tracer particles from the alveolar region of the rabbit respiratory tract. The technique uses a fixed detector for noninvasive, external monitoring. Validation of the method is presented, as is the clearance pattern of 3.5-micron latex particles as measured for 56 days postexposure. The clearance of latex deposited within the alveolar region can be described by two phases within this time frame, having half-times of 4.9 and 30.1 days, respectively. Clearance of latex initially deposited on the tracheobronchial tree was essentially complete by 2 days after exposure.
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| http://dx.doi.org/10.1016/0272-0590(86)90155-7 | DOI Listing |
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