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Bioenergetic theory of prostate malignancy.

Prostate

September 1994

Department of Physiology, University of Maryland Dental School, Baltimore 21201.

Normal and benign prostate hyperplasia (BPH) prostate is characterized by the presence of extraordinarily high levels of citrate. Presumably, this results from the inability of the prostate epithelial cells to oxidize citrate due to a limiting mitochondrial (m-) aconitase. In contrast, prostate carcinoma (CA) is not characterized by high citrate levels.

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