AI Article Synopsis
- The study confirms that parvalbumin (PV) levels, which are markers for certain brain cells, are significantly reduced in the prefrontal cortex and hippocampus of various animal models used for schizophrenia (SCZ).
- Different types of models (pharmacological, neurodevelopmental, and genetic) consistently showed these reductions, particularly highlighting the impact of NMDA receptor antagonism and certain genetic mutations.
- The research also indicates that male rodents tend to show more PV reductions in response to pharmacological models, while there is a lack of studies on female rodents in this context.
Article Abstract
Background: Consistent with postmortem findings in patients, most animal models for schizophrenia (SCZ) present abnormal levels of parvalbumin (PV), a marker of fast-spiking GABAergic interneurons, in the prefrontal cortex (PFC) and hippocampus (HIP). However, there are discrepancies in the literature. PV reductions lead to a functional loss of PV interneurons, which is proposed to underly SCZ symptoms. Given its complex etiology, different categories of animal models have been developed to study SCZ, which may distinctly impact PV levels in rodent brain areas.
Study Design: We performed a quantitative meta-analysis on PV-positive cell number/density and expression levels in the PFC and HIP of animal models for SCZ based on pharmacological, neurodevelopmental, and genetic manipulations.
Results: Our results confirmed that PV levels are significantly reduced in the PFC and HIP regardless of the animal model. By categorizing into subgroups, we found that all pharmacological models based on NMDA receptor antagonism decreased PV-positive cell number/density or PV expression levels in both brain areas examined. In neurodevelopmental models, abnormal PV levels were confirmed in both brain areas in maternal immune activation models and HIP of the methylazoxymethanol acetate model. In genetic models, negative effects were found in neuregulin 1 and ERBB4 mutant mice in both brain regions and the PFC of dysbindin mutant mice. Regarding sex differences, male rodents exhibited PV reductions in both brain regions only in pharmacological models, while few studies have been conducted in females.
Conclusion: Overall, our findings support deficits in prefrontal and hippocampal PV interneurons in animal models for SCZ.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10754178 | PMC |
| http://dx.doi.org/10.1093/schbul/sbad123 | DOI Listing |
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