AI Article Synopsis
- * Researchers measured thrombin activity in blood clots washed during stroke treatment, finding that changes in thrombin levels could indicate where the clot originated.
- * The study suggests that the difference in thrombin levels is linked to the clot's location, with higher blood flow areas washing out thrombin, while lower flow areas retain it.
Article Abstract
Endovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.
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