We consider a disk-like Janus particle self-driven by a force of constant magnitude f, but an arbitrary direction depending on the stochastic rotation of the disk. The particle diffuses in a two-dimensional channel of varying width 2h(x). We applied the procedure mapping the 2+1-dimensional Fokker-Planck equation onto the longitudinal coordinate x; the result is the Fick-Jacobs equation extended by the spatially dependent effective diffusion constant D(x) and an additional effective potential -γ(x), derived recursively within the mapping procedure. Unlike the entropic potential ∼lnh(x), γ(x) becomes an increasing or decreasing function also in periodic channels, depending on the asymmetry of h(x) and thus it visualizes the net force driving the ratchet current. We demonstrate the appearance of the ratchet effect on a trial asymmetric channel; our theory is verified by a numerical solution of the corresponding Fokker-Planck equation. Isotropic driving force f results in the monotonic decrease of the ratchet current with a growing ratio α=D_{R}/D_{T} of the rotation and the translation diffusion constants; asymptotically going ∼1/α^{2}. If we allow anisotropy of the force, we can observe the current reversal depending on α.
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http://dx.doi.org/10.1103/PhysRevE.108.014606 | DOI Listing |
Genetics
January 2025
Interfaculty Bioinformatics Unit, University of Bern, Bern 3012, Switzerland.
Purifying selection is a critical factor in shaping genetic diversity. Current theoretical models mostly address scenarios of either very weak or strong selection, leaving a significant gap in our knowledge. The effects of purifying selection on patterns of genomic diversity remain poorly understood when selection against deleterious mutations is weak to moderate, particularly when recombination is limited or absent.
View Article and Find Full Text PDFBMJ Glob Health
December 2024
Collaborative Centre for Climate, Health and Sustainable Care, University of Toronto, Toronto, Ontario, Canada.
Net Zero is the dominant framework for organising health system decarbonisation. Yet throughout Net Zero's rise to prominence, greenhouse gas emissions have remained on a dangerous trajectory. In this analysis, we synthesise strands of Net Zero critique from the climate policy literature, examine their implications for health systems and briefly present an alternative framework for decarbonisation.
View Article and Find Full Text PDFRes Sq
November 2024
Holonyak Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.
A long-unrealized goal in solid-state nanopore sensing is to achieve out-of-plane electrical sensing and control of DNA during translocation, which is a prerequisite for base-by-base ratcheting that enables DNA sequencing in biological nanopores. Two-dimensional (2D) heterostructures, with their capability to construct out-of-plane electronics with atomic layer precision, are ideal yet unexplored candidates for use as electrical sensing membranes. Here we demonstrate a nanopore architecture using a vertical 2D heterojunction diode consisting of p-type WSe on n-type MoS.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Extreme Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Floating microplastics (MPs) have recently become a major concern in marine pollution; however, current filter-based technology is hardly effective for directly removing such MPs from the water surface because of specific mesh size and clogging issues. This paper introduces a new skimming concept for removing floating MPs utilizing capillary force mediated by the elevation of a hydrophilic ratchet at the air-water interface. MPs floating near the ratchet surface are spontaneously forced toward the ratchet with a concave water meniscus, driven by the Cheerios effect.
View Article and Find Full Text PDFPhys Rev E
September 2024
School of Physics and Astronomy, Beijing Normal University, Beijing 100875, China.
Microscopic particle separation plays a vital role in various scientific and industrial domains. Conventional separation methods relying on external forces or physical barriers inherently exhibit limitations in terms of efficiency, selectivity, and adaptability across diverse particle types. To overcome these limitations, researchers are constantly exploring new separation approaches, among which ratchet-based separation is a noteworthy method.
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