Peptide-lipid hybrid vesicles with stimuli-responsive phase separation for controlled membrane functions.

Chem Commun (Camb)

Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.

Published: August 2023

A disulfide-tethered peptide-lipid conjugate self-assembled into a homogeneously distributed peptide-lipid hybrid vesicle. Upon dithiothreitol treatment, the homogeneous peptide-lipid membrane spontaneously divided into lipid-rich and peptide-rich domains, while the vesicle retained its size and shape. Membrane phase separation enhanced temperature-dependent cargo release.

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Source
http://dx.doi.org/10.1039/d3cc02954aDOI Listing

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