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The application of design of experiments and artificial neural networks in the evaluation of the impact of acidic conditions on cloud point extraction.
J Chromatogr A
January 2025
Department of Physical Pharmacy and Pharmacokinetics, Poznań University of Medical Sciences, Rokietnicka 3 Street, Poznań 60-806, Poland. Electronic address:
This study aimed to analyze the impact of acidic conditions on the recovery of ciprofloxacin and levofloxacin for cloud point extraction with the Design of Experiments and Artificial Neural Networks. The design included 27 experiments featuring three repetitions of the central point for both drugs. The tested parameters included Triton X-114 concentration, HCl concentration, NaCl concentration, and incubation temperature, which were coded at five levels.
View Article and Find Full Text PDFDisposition of enrofloxacin in plasma, pulmonary epithelial lining fluid, peritoneal fluid, and cerebrospinal fluid of healthy mares.
Am J Vet Res
January 2025
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA.
Objective: To investigate the disposition of enrofloxacin and its active metabolite, ciprofloxacin, in plasma, pulmonary epithelial lining fluid (PELF), peritoneal fluid, and CSF in horses following IV administration of enrofloxacin at doses of 5 mg/kg and 7.5 mg/kg of body weight.
Methods: 6 healthy, mature mares were randomly assigned to receive a single dose of enrofloxacin at either 5 mg/kg or 7.
The Effect of Fluoroquinolones on Aortic Aneurysm and Dissection.
Cureus
November 2024
Vascular Surgery, University of Colorado Anschutz Medical Center, Colorado, USA.
Fluoroquinolones (FQs) are a widely prescribed class of antibiotics including ciprofloxacin, levofloxacin, and ofloxacin. They are commonly used to treat a variety of infections worldwide. Known for their broad-spectrum antimicrobial activity, as well as excellent pharmacokinetics and bioavailability, the use of FQs has risen significantly.
View Article and Find Full Text PDFStimuli-responsive dual-drug loaded microspheres with differential drug release for antibacterial and wound repair promotion.
Colloids Surf B Biointerfaces
April 2025
Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China. Electronic address:
The healing of infected wounds is a complex and dynamic process requiring tailored treatment strategies that address both antimicrobial and reparative needs. Despite the development of numerous drugs, few approaches have been devised to optimize the timing of drug release for targeting distinct phases of infection control and tissue repair, limiting the overall treatment efficacy. Here, a stimuli-responsive microsphere encapsulating dual drugs was developed to facilitate differential drug release during distinct phases of antibacterial and repair promotion, thereby synergistically enhancing wound healing.
View Article and Find Full Text PDFEvaluation of the Antibacterial and Antioxidant Properties of Chemical Constituents of the Roots of : An Integrated Approach of Experimental and Computational Study.
Biochem Res Int
December 2024
Department of Biomaterials, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, India.
is a medicinal plant used for the treatment of malaria, toothache, and stomach problems. The root parts of the plant are also used for healing liver disorders. Silica gel chromatography separation of CHCl/MeOH (1:1) and MeOH extracts of roots of result in the isolation of three compounds, namely, bergenin (), -sitosterol (), and epigallocatechin 3-gallate (), reported herein for the first time from the plant.
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