Ultrasensitive and rapid detection of biomarkers is among the upmost priorities in promoting healthcare advancements. Improved sensitivity of photonic sensors based on two-dimensional (2D) materials have brought exciting prospects for achieving real-time and label-free biosensing at dilute target concentrations. Here, we report a high-sensitivity surface plasmon resonance (SPR) RNA sensor using metallic 2D GeP nanosheets as the sensing material. Theoretical evaluations revealed that the presence of GeP nanosheets can greatly enhance the plasmonic electric field of the Au film thereby boosting sensing sensitivity, and that optimal sensitivity (146° RIU) can be achieved with 3-nm-thick GeP. By functionalizing GeP nanosheets with specific cDNA probes, detection of SARS-CoV-2 RNA sequences were achieved using the GeP-based SPR sensor, with high sensitivity down to a detection limit of 10 aM and excellent selectivity. This work demonstrates the immense potential of GeP-based SPR sensors for advanced biosensing applications and paves the way for utilizing GeP nanosheets in novel sensor devices.
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| http://dx.doi.org/10.1016/j.jcis.2023.08.064 | DOI Listing |
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An Ultrasensitive SPR biosensor for RNA detection based on robust GeP nanosheets.
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