The synthesis of peptoids possessing multiple -inducing monomers with alkylammonium side chains is reported, where chloropropyl side chains are diversified on a solid support by late-stage S2 displacements with amines. The conditions were optimized for a wide variety of primary, secondary, and tertiary alkyl amine nucleophiles. We also demonstrated that multiple chloride displacements could be achieved on sequences possessing -inducing -aryl- and -imino glycine monomers.
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| http://dx.doi.org/10.1021/acs.orglett.3c02393 | DOI Listing |
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