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http://dx.doi.org/10.1001/jamainternmed.2023.3795 | DOI Listing |
J Funct Morphol Kinesiol
December 2024
Centro Universitario de la Ciénega, Universidad de Guadalajara, Avenida Universidad 1115, Ocotlan 47810, Jalisco, Mexico.
: The objective of this paper is to introduce a method to measure the force or pressure over the carpal tunnel indirectly, using a new device to drive the pointer of a computer system. The measurements were compared with those obtained using an ergonomic mouse. Simultaneously, measurements of muscular stress on the digitorum extensor muscle were performed to correlate the applied force against muscle activity.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Université Côte d'Azur, CNRS, Institut de Physique de Nice, 06200 Nice, France.
This study introduces a novel method to investigate in situ light transport within optically thick ensembles of cold atoms, exploiting the internal structure of alkaline-earth metals. A method for creating an optical excitation at the center of a large atomic cloud is demonstrated, and we observe its propagation through multiple scattering events. In conditions where the cloud size is significantly larger than the transport mean free path, a diffusive regime is identified.
View Article and Find Full Text PDFACS Nanosci Au
December 2024
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
RNA-based agents (siRNA, miRNA, and mRNA) can selectively manipulate gene expression/proteins and are set to revolutionize a variety of disease treatments. Nanoparticle (NP) platforms have been developed to deliver functional mRNA or siRNA inside cells to overcome their inherent limitations. Recent studies have focused on siRNA to knock down proteins causing drug resistance or mRNA technology to introduce tumor suppressors.
View Article and Find Full Text PDFNuclear deformation by osmotic shock or necrosis activates the cytosolic phospholipase A2 (cPla2) nuclear shape sensing pathway, a key regulator of tissue inflammation and repair. Ca²⁺ and inner nuclear membrane (INM) tension (T ) are believed to mediate nucleoplasmic cPla2 activation. The concept implies that T persists long enough to stimulate cPla2-INM adsorption.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Department of Chemical and Biological Engineering, University of Ottawa, 161 Louis Pasteur, Ottawa, Ontario K1N 6N5, Canada.
Developing sustainable electronics requires using materials that are either recyclable or biodegradable, without compromising on electrical performance. Here, we introduce a solution-processed biodegradable polymer blend consisting of a diketopyrrolopyrrole-based semiconducting polymer (DPP2T) and different mixtures of two biodegradable polymers, polycaprolactone (PCL) and polylactic acid (PLA). We find that controlling the ratio of components enables a reduction in semiconductor polymer loading (∼70:80% reduction) while maintaining or improving field-effect transistor performance.
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