AI Article Synopsis
- The study aimed to evaluate the clinical features and tear film biomarkers in patients experiencing chronic dry eye disease (DED) after undergoing femtosecond laser-assisted LASIK (FS-LASIK).
- Participants were categorized into three groups: those with chronic DED post-FS-LASIK, those with DED not related to FS-LASIK, and a normal control group, with assessments conducted using various questionnaires and specific tests for ocular surface parameters and cytokine levels.
- Results indicated that patients with chronic DED after FS-LASIK exhibited greater epithelial damage and elevated levels of certain inflammatory cytokines and neuropeptides, despite reporting milder ocular symptoms compared to the DED group without FS-LASIK, suggesting the involvement
Article Abstract
Purpose: To investigate clinical characteristics and tear film biomarkers of patients with chronic dry eye disease (DED) following femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK).
Methods: Patients were divided into the chronic DED after FS-LASIK (n = 36), DED without FS-LASIK (n = 39), and normal control (without FS-LASIK; n = 34) groups. Dry eye, pain, and psychological-related symptoms were evaluated using the Ocular Surface Disease Index (OSDI), Numerical Rating Scale (NRS), Neuropathic Pain Symptom Inventory Modified for the Eye (NPSI-Eye), and Hamilton Anxiety Rating Scale (HAMA) questionnaires. Ocular surface parameters, tear cytokines, and neuropeptide concentrations were evaluated with specific tests.
Results: The DED after FS-LASIK group showed higher corneal fluorescein staining scores, but lower OSDI and NPSI-Eye scores than the DED without FS-LASIK group (all < .05). Corneal sensitivity and nerve density decreased in the DED after FS-LASIK group (all < .01). Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-17A, IL-23, alpha-melanocyte stimulating hormone (α-MSH), oxytocin, and substance P levels were highest in the DED after FS-LASIK group, followed by the DED without FS-LASIK and normal control groups (all < .05). Interferon-γ and neurotensin levels were only significantly higher in the DED after FS-LASIK group (all < .05).
Conclusions: Patients with chronic DED after FS-LASIK showed milder ocular symptoms, greater epithelial damage, and higher levels of tear inflammatory cytokines and neuropeptides than patients with DED without FS-LASIK, indicating that the nervous and immune systems may play significant roles in FS-LASIK-related chronic DED development. .
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| http://dx.doi.org/10.3928/1081597X-20230717-02 | DOI Listing |
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Analysis of Clinical Characteristics and Neuropeptides in Patients with Dry Eye with and without Chronic Ocular Pain after FS-LASIK.
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Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Department of Ophthalmology, Peking University Third Hospital, Peking University Health Science Center, Institute of Medical Technology, 49 North Garden Road, Haidian District, Beijing, 100191, China.
Introduction: Chronic ocular pain, particularly prevalent in patients with dry eye disease and post-femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) surgery, presents with unclear clinical characteristics and an undefined pathogenesis. In this study, we aimed to compare clinical characteristics and tear neuropeptide concentrations in patients with dry eye disease (DED) with and without chronic ocular pain following FS-LASIK, and investigate correlations between ocular pain, clinical characteristics, and tear neuropeptide levels.
Methods: Thirty-eight post-FS-LASIK patients with DED were assigned to two groups: those with chronic ocular pain and those without chronic ocular pain.
Moisture chamber goggles for the treatment of postoperative dry eye in patients receiving SMILE and FS-LASIK surgery.
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Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Shuaifuyuan 1, Beijing, 100005, Dongcheng District, China.
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View Article and Find Full Text PDFTo evaluate the change of total antioxidant capacity (TAC) and ascorbic acid (AA) between femtosecond laser in situ keratomileusis (FS-LASIK) and laser-assisted lenticule extraction (LALEX). A prospective non-randomized study was conducted, and 33 and 75 eyes that had undergone FS-LASIK or LALEX surgeries were enrolled, respectively. The tear films near corneal incisions were collected, and the concentrations of TAC and AA were determined.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the clinical features and tear film biomarkers in patients experiencing chronic dry eye disease (DED) after undergoing femtosecond laser-assisted LASIK (FS-LASIK).
- Participants were categorized into three groups: those with chronic DED post-FS-LASIK, those with DED not related to FS-LASIK, and a normal control group, with assessments conducted using various questionnaires and specific tests for ocular surface parameters and cytokine levels.
- Results indicated that patients with chronic DED after FS-LASIK exhibited greater epithelial damage and elevated levels of certain inflammatory cytokines and neuropeptides, despite reporting milder ocular symptoms compared to the DED group without FS-LASIK, suggesting the involvement
Short-Term Impact of FS-LASIK and SMILE on Dry Eye Metrics and Corneal Nerve Morphology.
Cornea
July 2020
Optometry & Vision Sciences Group, School of Life & Health Sciences, Aston University, Birmingham, United Kingdom.
Purpose: To analyze the short-term (up to 1 month) clinical outcomes in patients undergoing corneal laser refractive surgery and the impact on dry eye disease (DED) metrics and corneal nerves using in vivo confocal microscopy (IVCM).
Methods: The unaided distance visual acuity, corrected distance visual acuity, and spherical equivalent refraction (SEQ) were determined in 16 and 13 patients undergoing FS-LASIK and SMILE, respectively. DED metrics assessed were Ocular Surface Disease Index, Dry Eye Questionnaire 5-items (DEQ-5), tear film osmolarity, tear meniscus height, noninvasive keratograph breakup time (NIKBUT), ocular staining, and meibomian gland atrophy.
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