AI Article Synopsis
- - The study investigates how the expression of pyroptosis-related lncRNAs affects the prognosis and immune response in cutaneous melanoma (CM) patients.
- - A prognostic risk model was developed and validated using eight identified pyroptosis-related lncRNAs, revealing that patients in the low-risk group have a higher overall survival rate.
- - This model not only enhances the prediction of CM patient outcomes but also suggests new potential therapeutic targets for treatment.
Article Abstract
To explore whether the expression of pyroptosis-related lncRNAs makes a difference in the prognosis and antitumor immunity of cutaneous melanoma (CM) patients. A series of analyses were conducted to establish a prognostic risk model and validate its accuracy. Immune-related analyses were performed to further assess the associations among immune status, tumor microenvironment and the prognostic risk model. Eight pyroptosis-related lncRNAs relevant to prognosis were ascertained and applied to establish the prognostic risk model. The low-risk group had a higher overall survival rate. The established prognostic risk model presents better prediction ability for the prognosis of CM patients and provides new possible therapeutic targets for CM.
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| http://dx.doi.org/10.2217/epi-2023-0139 | DOI Listing |
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