Two pairs of new bisabolane-type sesquiterpenoids, (+)-aspersydowin A (7S) [(+)-1], (-)-aspersydowin A (7R) [(-)-1], (+)-aspersydowin B (7S,11S) [(+)-2], (-)-aspersydowin B (7R,11R) [(-)-2], along with six known compounds (1-8) were isolated from the fungus Aspergillus sydowii. Compounds 1 and 2 are enantiomers resolved by the Chiralpak IC, using a hexane- propan-2-ol mobile phase. The structure of 1 and 2 with absolute configuration were assigned tentatively by 1D ( H, C, and DEPT) & 2D (HSQC, H- H COSY, HMBC, and NOESY) NMR data analyses and ECD calculations. Compounds 1-8 were screened for the biological activities in vitro. The results showed that compounds 3, 4 and 8 exhibited immunosuppressive activities with IC values of 10.9, 17.6 and 13.4 μM, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbdv.202301047 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Two Pairs of New Bisabolane-Type Sesquiterpenoids from Aspergillus sydowii.
Chem Biodivers
December 2023
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P. R. China.
Two pairs of new bisabolane-type sesquiterpenoids, (+)-aspersydowin A (7S) [(+)-1], (-)-aspersydowin A (7R) [(-)-1], (+)-aspersydowin B (7S,11S) [(+)-2], (-)-aspersydowin B (7R,11R) [(-)-2], along with six known compounds (1-8) were isolated from the fungus Aspergillus sydowii. Compounds 1 and 2 are enantiomers resolved by the Chiralpak IC, using a hexane- propan-2-ol mobile phase. The structure of 1 and 2 with absolute configuration were assigned tentatively by 1D ( H, C, and DEPT) & 2D (HSQC, H- H COSY, HMBC, and NOESY) NMR data analyses and ECD calculations.
View Article and Find Full Text PDFBisabolane-Type Sesquiterpenoids with a Tetrahydrofuran or Tetrahydropyran Ring from .
J Nat Prod
June 2023
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China.
Phytochemical investigation of the aerial parts of resulted in the isolation of 23 new highly oxidized bisabolane-type sesquiterpenoids (-). Structures were determined by interpretation of spectroscopic data, single-crystal X-ray diffraction analysis, and time-dependent density functional theory electronic circular dichroism calculations. Most compounds possess a rare tetrahydrofuran (-) or tetrahydropyran ring (-).
View Article and Find Full Text PDFNew Bisabolane-Type Sesquiterpenoids from and Their Anti-Atherosclerotic Activity.
Molecules
March 2023
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
To explore the sesquiterpenoids in L. and their activity related to anti-atherosclerosis. The chemical compounds of the rhizomes of were separated and purified by multiple chromatography techniques.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!