This study presents a green synthesis approach for the fabrication of zinc oxide-silver nanoparticles (ZnO-Ag-NPs) using fruit peels extract as a natural reducing and stabilizing agent. This eco-friendly method offers a sustainable alternative to conventional methods that often employ toxic or hazardous chemicals. Antibacterial and anti-cancer activities of the green synthesized nanoparticles were then assessed . X-ray diffraction confirmed the production of ZnO-Ag-NPs with increasing crystallinity in higher pH values. The ZnO-Ag-NPs were found to be agglomerated with spherical Ag-NPs. Fourier Transform Infrared (FTIR) spectra revealed a broad band in ZnO-Ag-NPs ranging from 400 to 530 cm with reduced intensity as compared to ZnO-NPs, indicating the formation of Ag-NPs on the surface of ZnO-NPs. The synthesized ZnO-Ag-NPs exhibited potent antibacterial activity against a broad spectrum of bacterial strains, particularly Gram-positive bacteria, with superior inhibition activity compared to ZnO-NPs. Moreover, ZnO-Ag-NPs showed a dose-dependent anti-proliferative effect on colorectal-, lung-, and cervical cancer cells. ZnO-Ag-NPs showed significantly greater efficacy in inhibiting cancer cell growth at a lower concentration of 31.25 μg/mL, compared to ZnO-NPs which required over 500 μg/mL, possibly due to the presence of silver nanoparticles (Ag-NPs). The results obtained from this study demonstrate the potential of green synthesis approaches in the fabrication of therapeutic nanomaterials for cancer treatment, as well as other biomedical applications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421725 | PMC |
| http://dx.doi.org/10.3389/fmicb.2023.1194292 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The protective effect of zinc oxide nanoparticles on boar sperm during preservation at 17 °C.
Anim Reprod
January 2025
Hebei Key Laboratory of Animal Diversity, College of Life Sciences, Langfang Normal University, Hebei Langfang, China.
More than 90% of spermatozoa of boars in pork producing countries is stored in liquid at 17 °C; however, the quality of these spermatozoa is affected by bacterial breeding and oxidative damage. This study analyzed sperm quality and sperm capacitation after storage to study the effects of the effects of ZnO nanoparticles (ZnO NPs) supplementation on seminal plasma (SP)-free sperm preservation. We investigated the effects of adding 20, 50, 100 and 200 μg/mL of ZnO NPs to a seminal free boar sperm diluent over a 7-day period at 17 °C to assess the changes in non-capacitated/capacitated sperm quality parameters, antioxidant capacity, ATP content and extent of protein tyrosine phosphorylation.
View Article and Find Full Text PDFThree different methods for ZnO-RGO nanocomposite synthesis and its adsorption capacity for methylene blue dye removal in a comparative study.
BMC Chem
January 2025
Environmental Applications of Nanomaterial's Lab., Department of Chemistry, Faculty of Science, Aswan University, Aswan, 81528, Egypt.
Water is one of the vital needs of life. However, due to rapid industrialization, urbanization and lack of awareness, the world population now facing the threat of water shortage. To ensure that future living conditions are preserved, it is crucial to reduce water pollution and protect the ecosystem.
View Article and Find Full Text PDFSynergistic Effect of Sugarcane Bagasse and Zinc Oxide Nanoparticles on Eco-Remediation of Cadmium-Contaminated Saline Soils in Wheat Cultivation.
Plants (Basel)
December 2024
Department of Applied Plant Biology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi Str. 138, 4032 Debrecen, Hungary.
Soil contamination with cadmium (Cd) and salinity poses a significant challenge, affecting crop health and productivity. This study explores the combined application of sugarcane bagasse (SCB) and zinc oxide nanoparticles (ZnO NPs) to mitigate the toxic effects of Cd and salinity in wheat plants. Field experiments conducted in Cd-contaminated saline soils revealed that the application of SCB (0, 5, and 10 t ha) and ZnO NPs (0, 12.
View Article and Find Full Text PDFKinetics, central composite design and artificial neural network modelling of ciprofloxacin antibiotic photodegradation using fabricated cobalt-doped zinc oxide nanoparticles.
Sci Rep
January 2025
Environment Division, National Institute of Oceanography and Fisheries (NIOF), Kayet Bey, Elanfoushy, Alexandria, Egypt.
Article Synopsis
- The study focused on creating and testing Cobalt-doped zinc oxide nanoparticles as a photocatalyst for degrading the antibiotic ciprofloxacin (CIPF) under visible LED light.
- It was found that 10% Cobalt-doped ZnO nanoparticles were the most effective, achieving over 99% degradation of CIPF in just 90 minutes, and maintained their efficiency across three cycles of use.
- The research also optimized the conditions for maximum degradation efficiency using statistical methods and simulated data using Artificial Neural Networks, achieving a strong correlation for the model’s accuracy.
Cytotoxicity and Antimicrobial Efficacy of Fe-, Co-, and Mn-Doped ZnO Nanoparticles.
Molecules
December 2024
College of Medicine and Public Health, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.
Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanoparticulate materials due to their antimicrobial properties. However, the current use of ZnO NPs is hindered by their potential cytotoxicity concerns, which are likely attributed to the generation of reactive oxygen species (ROS) and the dissolution of particles to ionic zinc. To reduce the cytotoxicity of ZnO NPs, transitional metals are introduced into ZnO lattices to modulate the ROS production and NP dissolution.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!