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| http://dx.doi.org/10.1016/j.jdin.2023.06.007 | DOI Listing |
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Slit skin smear versus anti-phenolic glycolipid-I serology in diagnosis of leprosy: a cross sectional study.
Arch Dermatol Res
December 2024
Department of Dermatology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.
Leprosy is a chronic infectious disease which mainly affects the skin, nasal mucosa, and peripheral nerves. The aim of this study was to compare between the efficacies of serum anti-phenolic glycolipid 1 (APGL-I) level versus slit skin smear (SSS) in diagnosis of leprosy. This study involved 58 leprosy cases who were clinically examined, slit-skin smears were taken from all at diagnosis from four sites and APGL-I levels were seroassayed using ELISA.
View Article and Find Full Text PDFEvaluation of CD1a immunostaining in the diagnosis of cutaneous leishmaniasis caused by in Sri Lanka.
Parasitology
November 2024
Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease, routinely diagnosed by direct light microscopy. The sensitivity of this method is dependent on the number of parasites present in the lesion. Immunoexpression of CD1a surface antigen by amastigotes and its application as a diagnostic tool has been recently demonstrated in several species including , and .
View Article and Find Full Text PDFUnveiling inflammatory biomarkers in multibacillary leprosy: the role of lymphocyte-platelet ratio in predicting leprosy reactions.
Arch Dermatol Res
October 2024
Departamento de Ciências Farmacêuticas, Universidade Federal de São Paulo, Campus Diadema, Diadema, Brazil.
Article Synopsis
- Leprosy is a contagious disease causing physical disabilities and inflammatory episodes, but lacks definitive lab markers for diagnosing leprosy reactions, complicating its management.
- A study analyzed 67 patients with multibacillary leprosy, focusing on inflammatory biomarkers like lymphocyte-platelet ratio and systemic immune-inflammation index, using various diagnostic methods.
- Results indicated a positive association between leprosy reactions and the lymphocyte-platelet ratio, suggesting it could be a potential early indicator for recognizing these reactions, highlighting the need for further research.
Fever of unknown origin, blood and cerebrospinal fluid involvement: a leprosy case report.
Front Immunol
September 2024
Department of Mycobacterium, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology & Hospital for Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China.
Article Synopsis
- Leprosy is an infectious disease primarily affecting the skin and nerves, but it can also impact internal organs and tissues, leading to deformities and disabilities in severe cases.
- A 39-year-old male patient presented with fever, headache, and rash, prompting histopathological examinations and analysis of skin lesions.
- The patient was diagnosed with multibacillary leprosy and type II leprosy reaction, indicating a potential for bacteremia and the presence of leprosy-related genetic material in the cerebrospinal fluid and skin lesions.
qPCR detection of DNA in urine samples of leprosy patients using the gene target.
Front Mol Biosci
August 2024
Department of Biotechnology, Thiruvalluvar University, Vellore, India.
Background: Leprosy, a chronic infectious disease caused by , continues to pose a public health challenge in many parts of the world. Early and accurate diagnosis is crucial for effective treatment and prevention of disabilities associated with the disease. Molecular techniques such as PCR have demonstrated great potential as a diagnostic tool for directly detecting DNA in different clinical samples, providing better sensitivity and specificity than conventional diagnostic techniques.
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