AI Article Synopsis
- Single-cell analysis reveals differences in cell functions that are often missed in standard measurements, but there's a need for noninvasive methods to analyze chemical properties.
- Nitrogen-vacancy (NV) centers in diamond offer a promising solution by enabling NMR spectroscopy on very small sample sizes.
- The article reviews advances in NV-based quantum sensing and suggests ways to improve sensitivity for detecting chemicals in individual cells, pointing towards future applications in single-cell studies.
Article Abstract
Single-cell analysis can unravel functional heterogeneity within cell populations otherwise obscured by ensemble measurements. However, noninvasive techniques that probe chemical entities and their dynamics are still lacking. This challenge could be overcome by novel sensors based on nitrogen-vacancy (NV) centers in diamond, which enable nuclear magnetic resonance (NMR) spectroscopy on unprecedented sample volumes. In this perspective, we briefly introduce NV-based quantum sensing and review the progress made in microscale NV-NMR spectroscopy. Last, we discuss approaches to enhance the sensitivity of NV ensemble magnetometers to detect biologically relevant concentrations and provide a roadmap toward their application in single-cell analysis.
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| http://dx.doi.org/10.1016/j.copbio.2023.102975 | DOI Listing |
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