AI Article Synopsis
- The glymphatic system is important for clearing toxins from the brain, with perivascular spaces (PVSs) being crucial for its function, particularly during sleep.
- Recent studies have used advanced imaging to explore PVS structures and their links to various diseases, highlighting the significant role of sleep in the effectiveness of the glymphatic system.
- Dysfunction in the glymphatic system might be related to neuroinflammation, neurodegenerative diseases, and cognitive issues, indicating that improving sleep could be a potential strategy for addressing these conditions.
Article Abstract
Purpose Of Review: The glymphatic system is hypothesized to act as the brain's filtration system to remove toxic solutes that accumulate throughout the day. Perivascular spaces (PVSs) play a fundamental role in the ability of the glymphatic system to function, and sleep influences the effectiveness of this system. This article reviews the complexity of the interplay between sleep, the glymphatic system, and PVS.
Recent Findings: New imaging techniques have illuminated the structure of PVS and their associations with differing disease states. Research has shown that sleep may play a key role in the function of PVS and the influence of adenosine, astrocyte, and aquaporin-4 channel in the function of the glymphatic system. Emerging data suggest that differing pathological states such as neuroinflammatory conditions, neurodegenerative diseases, and cognitive dysfunction may be associated with underlying glymphatic system dysfunction, and sleep disorders could be a potential intervention target.
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| http://dx.doi.org/10.1007/s11910-023-01293-z | DOI Listing |
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