AI Article Synopsis
- - Amino acids are crucial for protein synthesis and are also important precursors for nitrogen-containing compounds, but their breakdown (catabolism) plays a significant role in various metabolic processes, which is still being researched.
- - Recent studies highlight how gut microbiota influence amino acid metabolism, the transcriptional control mechanisms involved, and the role of specific miRNAs in regulating enzymes that degrade amino acids.
- - The products of amino acid catabolism can affect metabolism, including gene regulation related to the immune response, issues linked to obesity like insulin resistance, and thermoregulation.
Article Abstract
Amino acids have been extensively studied in nutrition, mainly as key elements for maintaining optimal protein synthesis in the body as well as precursors of various nitrogen-containing compounds. However, it is now known that amino acid catabolism is an important element for the metabolic control of different biological processes, although it is still a developing field to have a deeper understanding of its biological implications. The mechanisms involved in the regulation of amino acid catabolism now include the contribution of the gut microbiota to amino acid oxidation and metabolite generation in the intestine, the molecular mechanisms of transcriptional control, and the participation of specific miRNAs involved in the regulation of amino acid degrading enzymes. In addition, molecules derived from amino acid catabolism play a role in metabolism as they are used in the epigenetic regulation of many genes. Thus, this review aims to examine the mechanisms of amino acid catabolism and to support the idea that this process is associated with the immune response, abnormalities during obesity, in particular insulin resistance, and the regulation of thermogenesis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421169 | PMC |
| http://dx.doi.org/10.3390/nu15153378 | DOI Listing |
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