Alinidine, the N-allyl derivative of clonidine, reduces heart rate in animals and man by a selective action on the sinoatrial node. In this study, in the presence of caesium, which blocks the time dependent inward current activated by hyperpolarisation (ih or if), alinidine still caused a concentration related bradycardia in the rabbit sinoatrial node. Within the clinical range of concentrations of alinidine the curve relating heart rate to alinidine concentration in the presence of caesium was parallel to that observed in its absence. It is concluded that the alinidine induced bradycardia cannot be attributed to blockade of ih.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/cvr/20.5.375 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Interaction of cesium compounds with abundant inorganic compounds of atmosphere: Effect on cloud formation potential and settling.
J Hazard Mater
January 2025
Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai 400085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India.
Experiments were conducted in controlled laboratory conditions to determine the size-resolved CCN (Cloud Condensation Nuclei) activity of sub micrometer-sized aerosols containing nuclear fission products (CsI and CsOH) and abundant ambient inorganic aerosols ammonium sulphates ((NH)SO), ammonium chloride (NHCl), sodium nitrate (NaNO), and sodium chloride (NaCl). The presence of these atmospheric-relevant compounds internally mixed with fission product compounds has the potential to affect the capacity of ambient particulates of aerosols to absorb water and function as CCN. Once in the atmosphere, the dynamics of airborne radionuclides and subsequently their fate gets affected by dry and wet deposition processes.
View Article and Find Full Text PDFFacile synthesis of unknown 6,7-dihydrofuro[3,4-]pyridines and 3,4-diaryloylpyridines from -homopropargylic β-enaminones.
Org Biomol Chem
January 2025
Department of Chemistry, Faculty of Arts and Science, Middle East Technical University, 06800 Ankara, Turkey.
In this paper, we have uncovered a new reaction of -homopropargylic β-enaminones, -(4-phenyl-3-butynyl)-β-enaminones. When subjected to a reaction with excess molecular iodine or -iodosuccinimide in the presence of cesium carbonate, -homopropargylic β-enaminones afford 6,7-dihydrofuro[3,4-]pyridines in low to moderate yields. The generation of two new C/O-C bonds during the reaction leads to the construction of unknown heterobicyclic 5,6-fused ring systems.
View Article and Find Full Text PDFRadiocaesium and radiostrontium transfer to an insect herbivore and an insect detritivore through holometabolous development: A comparison between the cabbage butterfly (Pieris brassicae) and the black soldier fly (Hermetia illucens).
Sci Total Environ
February 2025
Faculty of Environmental Sciences and Natural Resource Management, Norwegian University of Life Sciences, Ås, Norway.
The presence of the long-lived radionuclides Cs and Sr in ecosystems is a major environmental concern because bioavailable forms of the radionuclides are readily transferred to living organisms. The present study investigated how holometabolous insect development influences the fate of radiocaesium and radiostrontium by examining the behaviour of tracers (Cs and Sr) and stable elements during the larval feeding stage (21-23 days old), the pupal stage, and the adult stage. We aimed to evaluate the degree to which an herbivore or a detritivore food chain could serve as transfer pathways to higher trophic levels in terms of accumulation potential, and during which stage of development the accumulation potential is highest.
View Article and Find Full Text PDFUnraveling the Origin of Unusual Cs Atom Disorder in Cesium Octahedral Molybdenum Halide Cluster Compounds, Cs[{MoX}X] (X = Cl and Br).
Inorg Chem
January 2025
NIMS-CNRS-Saint-Gobain International Collaboration Center, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
In this study, we investigate structural disorder and its implications in metal cluster (MC)-based compounds, specifically focusing on Cs[{MoX}X] (X = Cl and Br). Utilizing synchrotron radiation X-ray diffraction, Fourier transform infrared spectroscopy, and luminescence measurements, we examined the incorporation of water molecules into these compounds and their effects on the crystal structure and optical properties. Our findings reveal that the presence of water molecules induces the lattice disorder, particularly the displacement of Cs atoms.
View Article and Find Full Text PDFFacile and Regioselective Deuteration of C2-Alkylated Imidazolium Salts in the Presence of Cesium Carbonate.
Chemistry
December 2024
Laboratory of Catalysis, MolSys Research Unit, Université de Liège, Institut de Chimie Organique (B6a), Allée du six Août 13, 4000, Liège, Belgium.
Thirteen imidazolium iodides bearing benzyl, mesityl, or 2,6-diisopropylphenyl substituents on their nitrogen atoms, and C-C alkyl chains on their C2 carbon atom were readily deuterated with DO as a cheap and non-toxic deuterium source in the presence of CsCO, a weak, innocuous, inorganic base. The isotopic exchange proceeded quickly and efficiently under mild, aerobic conditions to afford a range of aNHC and NHO precursors regioselectively labeled on their C2α exocyclic position and/or C4=C5 heterocyclic backbone. A "carbene-free" mechanism was postulated, in which the carbonate anion acts as a catalyst to activate an exocyclic, acidic C-H bond and ease a deuterium transfer from DO to the imidazolium salt in a concerted fashion.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!