and 's Interplay in the Human Gut: Bacterial Alliance or Competition? A Systematic Literature Review.

and spp. are two common bacterial pathogens populating the human microbiota. We possess scant data on how interacts with spp. in the gut microbiota in subjects colonized with or during a infection. We carried out a systematic review of studies on spp. and 's interaction in the gut microbiota and on the effect of spp. gut colonization on CDI development. Studies on spp. and 's interaction in the gut microbiota and on the effect of spp. gut colonization on CDI were searched using the search terms "clostridium", "clostridioides", "difficile" and "enterococcus" on the MEDLINE and SCOPUS databases. PubMed was searched until 1 May 2023. An English language restriction was applied. The risk of bias in the included studies was not assessed. Quantitative and qualitative information was summarized in textual descriptions. Fourteen studies, published from August 2012 to November 2022, on and spp.'s interaction in the gut microbiota met the inclusion criteria. The studies included in our systematic review reported evidence that the spp. intestinal burden represents a risk factor for the occurrence of CDI. There is supporting evidence that spp. play a role in CDI development and clinical outcomes.