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HM-P2 influences gestational gut microbiome and microbial metabolism.
Front Nutr
December 2024
National Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing, China.
Introduction: Human milk-derived probiotics are beneficial bacteria that provide gestational health benefits, for both pregnant women and their offspring. The study aims to investigate whether the administration of human milk-derived probiotic HM-P2 could effectively influence gestational health.
Methods: The gestational humanized microbiome model was built by fecal microbiome transplant from gestational women into germ-free (GF) mice.
Background: Ibezapolstat (IBZ) is a competitive inhibitor of the bacterial Pol IIIC enzyme in clinical development for treatment of infection (CDI). Previous studies demonstrated IBZ carries a favorable microbiome diversity profile compared to vancomycin (VAN). However, head-to-head comparisons with other CDI antibiotics have not been done.
View Article and Find Full Text PDFFusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer.
Cancer Cell
October 2024
Department of Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Digestive Disease and The Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:
Article Synopsis
- Microsatellite stable (MSS) colorectal cancers (CRCs) usually resist anti-PD-1 therapy, but the presence of the pathogen Fusobacterium nucleatum (Fn) makes these cancers more sensitive to treatment.
- Fecal microbiota transplantation (FMT) from patients with high levels of Fn to germ-free mice enhances anti-PD-1 effectiveness, suggesting a link between Fn and improved treatment response.
- Fn increases butyric acid production in tumors, which helps activate CD8 T cells by altering their function and reduces exhaustion, indicating that Fn may serve as a useful biomarker for predicting responses to anti-PD-1 therapy in MSS CRC patients.
Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice.
Sci China Life Sci
January 2025
State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
The human microbiota-associated (HMA) mice model, especially the germ-free (GF)-humanized mice, has been widely used to probe the causal relationships between gut microbiota and human diseases such as type 1 diabetes (T1D). However, most studies have not clarified the extent to which the reconstruction of the human donor microbiota in recipient mice correlates with corresponding phenotypic reproducibility. In this study, we transplanted fecal microbiota from five patients with T1D and four healthy people into GF mice, and microbiota from each donor were transplanted into 10 mice.
View Article and Find Full Text PDFLactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model.
J Am Soc Nephrol
January 2025
Renal Division, Key Laboratory of Renal Disease, Ministry of Health of China, Peking University Institute of Nephrology, Peking University First Hospital, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China.
Key Points: We generated a transgenic mouse model expressing the human IgA1 heavy chain, which has a hinge region with rich -linked glycosylation. After inflammatory stimulation, the mouse model showed elevated galactose-deficient IgA1 levels in the serum. Coupled with complement H factor mutant, the mice model exhibited glomerular lesions, associated with hematuria and albuminuria like IgA nephropathy.
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