Review: The role of male reproductive tract secretions in ruminant fertility.

Male fertility largely depends on the ability to produce sperm that can transmit the paternal information onto the next generation. However, the factors that are critical for sperm function and the subsequent development of healthy offspring are still not completely understood in ruminants. Importantly, sperm function is not completely encoded by germ cell DNA, but rather, depends on sequential acquisition, loss, and modification of elements through interaction with secretions from the testes, epididymides, and accessory glands (collectively termed seminal plasma). In addition, these secretions can play a role in the inheritance of paternal environmental effects by progeny. This is likely achieved directly, by the regulation of sperm epigenetic effectors, and indirectly, by altering the female environment in which the individual develops. This review will provide an overview of the different organs that contribute to seminal plasma in ruminants, and summarise how their secretions shape sperm function and modulate the female reproductive tract. Finally, some consideration will be given to the potential of paternal factors to affect embryo development and offspring health in ruminants.