AI Article Synopsis
- Long non-coding RNAs (lncRNAs) are gaining attention in cancer research, though there's still debate on how many functional non-coding RNAs exist and their roles in cells.
- Small nucleolar RNAs (snoRNAs), which are shorter and found mostly in the nucleolus, have been studied more extensively and are often encoded within introns of genes known as small nucleolar RNA host genes (SNHGs).
- The article delves into the biology of SNHGs, their significance in human cancers, and discusses the potential of snoRNAs as prognostic and diagnostic tools in various cancer types.
Article Abstract
Long non-coding RNAs (lncRNAs), which comprise most non-coding RNAs (ncRNAs), have recently become a focus of cancer research. How many functional ncRNAs exist is still a matter of debate. Although insufficient evidence supports that most lncRNAs function as transcriptional by-products, it is widely known that an increasing number of lncRNAs play essential roles in cells. Small nucleolar RNAs (snoRNAs), 60-300 nucleotides in length, have been better studied than long non-coding RNAs (lncRNAs) and are predominantly present in the nucleolus. Most snoRNAs are encoded in introns of protein- and non-protein-coding genes called small nucleolar RNA host genes (SNHGs). In this article, we explore the biology and characteristics of SNHGs and their role in developing human malignancies. In addition, we provide an update on the ability of these snoRNAs to serve as prognostic and diagnostic variables in various forms of cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.prp.2023.154679 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!