Cocaine abuse with its complications is a common problem that presents often in the emergency room. Complications of cocaine use can involve multiple systems. These complications can arise within each system simultaneously or at different times. We treated a patient who presented with symptoms of cerebrovascular accident and was found to have concomitant non-ST segment elevation myocardial infarction (NSTEMI). A 54-year-old male with medical history significant for hypertension and prior MI presented to emergency department with left leg and arm numbness first noticed when he woke up in the morning of presentation. He admitted using cocaine the night prior to presentation. Neurological exam was remarkable for decreased sensation to left extremities. His National Institute of Health Stroke Scale (NHISS) score was 1. Blood work was significant for an elevated troponin I of 1.74 ng/ml, and an elevated Creatinine of 2.34 mg/dl. CT head and MRI brain were negative for acute intracranial hemorrhage or radiological evidence of stroke. He was treated with aspirin, clopidogrel, statin and therapeutic enoxaparin for NSTEMI. His symptoms of left sided numbness resolved over the course of his stay. This case underscores why cocaine abuse should always be considered in the differential for patients presenting with symptoms suggestive of acute coronary syndrome or stroke, especially in young and middle-aged males.
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Alpha Psychiatry
November 2024
Old Age Psychiatry, Lancashire & South Cumbria NHS Foundation Trust, Preston, United Kingdom.
Addiction comes in various forms and can be related to substances like cocaine, opioids, alcohol, cannabis, amphetamine, and nicotine, as well as behaviors like gambling or sex addiction. The impact of addiction places increased economic and medical burdens on society. Currently, the management of addiction is more focused on symptomatic relief rather than targeting the reinforcing mechanisms of dependence on addictive substances and behaviors.
View Article and Find Full Text PDFNeurobiol Dis
January 2025
Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany; Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Heidelberg, Germany.
Addiction is a chronic and severe mental disorder with high gender- and sex-specificity. However, the pathogenesis of this disorder is not fully elucidated, and no targeted pharmacotherapy is available. A growing body of evidence points out the potential involvement of the ceramide system in the pathophysiology of addiction.
View Article and Find Full Text PDFLeg Med (Tokyo)
January 2025
Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna 40126 Bologna, Italy.
In this case report, the role of a myocardial bridge of the left anterior descending artery (LAD) and recent use of cannabis in a sudden death of a drug user is discussed, also considering the relevance of histopathological pulmonary findings. A 37-year-old man with a history of drug abuse was found dead in his house. External and autoptic examination were performed, as well as histologic and toxicologic analyses of tissues, organs and body fluids samples.
View Article and Find Full Text PDFDiabetes Metab
January 2025
Division of Diabetes, Nutrition and Metabolic Disorders, CHU Liège, Liège, Belgium; Division of Clinical Pharmacology, Centre for Interdisciplinary Research on Medicines (CIRM), Liège University, Liège, Belgium. Electronic address:
Background: Obesity is an increasing public health problem because of its high prevalence and associated morbidity and mortality. Two weight-loss strategies are currently used, either bariatric surgery or pharmacological therapy with glucagon-like peptide-1 receptor agonists (GLP-1RAs). Preclinical studies in rodents suggested an increased risk of additive disorders after bariatric surgery contrasting with a reduced risk with GLP-1RAs.
View Article and Find Full Text PDFHeliyon
January 2025
Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, Câmpus de São José dos Campos, São Paulo, Brazil.
Objective: This study aims to analyze saliva composition in crack users using vibrational spectroscopy.
Material And Methods: A total of 90 participants were meticulously selected and divided into three groups, each comprising 30 individuals. All participants met the criterion of having no observable clinical changes in the oral mucosa.
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