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Discovery of -Clerodane Diterpenoids from as Neuroprotective Agents against Ferroptosis and Neuroinflammation. | LitMetric

Discovery of -Clerodane Diterpenoids from as Neuroprotective Agents against Ferroptosis and Neuroinflammation.

J Nat Prod

Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.

Published: August 2023

AI Article Synopsis

Article Abstract

Twelve new -clerodane diterpenoids, eight undescribed methoxy/ethoxy acetal analogues, and one new -iridane monoterpenoid were isolated from . Their structures were elucidated using a combination of spectroscopic data, quantum chemical calculations, and X-ray crystallography. This research reveals the distinctive structural features of diterpenes, including distinct C rings and 4,18-double bonds, distinguishing them from diterpenes of other plants in the genus. Compound represents the first example of a 19(5→6)--clerodane formed through a Wagner-Meerwein rearrangement. The isolated compounds were assessed for their neuroprotective effects against RSL3-induced ferroptosis in HT22 cells and LPS-induced neuroinflammation in BV-2 cells. Notably, compound inhibits ferroptosis (EC = 10 μM) with a potentially new mechanism of action. The preliminary structure-activity relationship studies revealed that the furan-clerodane diterpenoids possess potential ferroptosis inhibitory activity, while the lactone-clerodanes do not. This study represents the first report of furan-containing clerodanes within the genus, providing fresh insights into the phytochemistry and pharmacological potential of .

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Source
http://dx.doi.org/10.1021/acs.jnatprod.3c00447DOI Listing

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