Introduction: The obturator internus muscle is frequently targeted for injective treatments such as botulinum toxin injections in the management of pain syndromes. However, there are controversies over injective method delivering injection to the muscle.
Method: A method called modified Sihler's method was used to stain the OI muscle in 16 specimens to reveal the intramuscular neural distribution of the muscle.
Result: The greatest intramuscular neural distribution was located on the 2/10-4/10 of the muscle in the medial edge of the obturator foramen (0/0) to the greater trochanter of the femur (10/10).
Conclusion: The result suggests that botulinum neurotoxin should be delivered in the intrapelvic portion of the obturator internus muscle. As most of the extrapelvic portion of the obturator muscle is composed of a tendinous portion, it should be considered unsuitable as an injection site by medical professionals.
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http://dx.doi.org/10.1007/s00276-023-03216-6 | DOI Listing |
Int J Mol Sci
November 2024
Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätstraße 19, 91054 Erlangen, Germany.
Human vocalization is a complex process that is still only partially understood. Previous studies have suggested the possibility of a localized neuromuscular network of the larynx. Here we investigate this structure in human dissection specimens using multiple immunofluorescence and transmission electron microscopy (TEM).
View Article and Find Full Text PDFJ Neural Eng
November 2024
Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, United States of America.
Neuroprostheses typically operate under supervised learning, in which a machine-learning algorithm is trained to correlate neural or myoelectric activity with an individual's motor intent. Due to the stochastic nature of neuromyoelectric signals, algorithm performance decays over time. This decay is accelerated when attempting to regress proportional control of multiple joints in parallel, compared with the more typical classification-based pattern recognition control.
View Article and Find Full Text PDFEur Spine J
November 2024
Department of Computer Engineering and Software Engineering, Polytechnique Montreal, Montreal, Canada.
Purpose: Lumbar paraspinal intramuscular fat (IMF) has emerged as a biological factor in low back pain (LBP). Traditional assessments measure IMF across the entire muscle or at specific levels and may miss key information on the role of IMF in LBP. Despite known variations across the lumbar spine, the three-dimensional (3D) distribution of IMF has not been characterized across people.
View Article and Find Full Text PDFCell Rep
November 2024
Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
Enteric neural stem cell (ENSC) therapy offers great promise for neurointestinal diseases; however, current isolation methods yield insufficient neurons for regenerative applications. Multiomic profiling of enteric glial cells (EGCs) suggests that subpopulations within myenteric ganglia (MyGa) are a reservoir of highly neurogenic ENSCs. Here, we describe protocols to enrich for intraganglionic EGCs by isolating intact fragments of MyGa, generating cultures with higher neuronal purity than traditional methodologies isolating intramuscular single cells (IM-SCs).
View Article and Find Full Text PDFNeurology
November 2024
From the Reference Center for Neuromuscular Diseases and ALS (E.F., E.D., S.A.), La Timone University Hospital, Marseille; UMR CNRS 7339 (E.F., C.P.M., M.G., D.B.), Center for Magnetic Resonance in Biology and Medicine, Marseille; CNRS, LIS (M.A.H., M.-E.B.), UMR 7286, Medicine Faculty (E.D.), and Inserm, GMGF (S.A.), Aix-Marseille University, France.
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