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Unveiling the Neural Environment in Cancer: Exploring the Role of Neural Circuit Players and Potential Therapeutic Strategies. | LitMetric

AI Article Synopsis

  • The immune environment in tumors has opened new possibilities for cancer treatment, but the neural environment around tumors is often neglected despite its role in cancer progression.
  • Neurotrophic factors released by cancer cells help nerve cells infiltrate the tumor microenvironment, promoting cancer cell growth, migration, and invasion via neurotransmitters.
  • Certain components of the neural circuits in cancers may serve as biomarkers for cancer aggressiveness; targeting them with inhibitors could reduce cancer morbidity and mortality, but more research is needed to assess the effectiveness of anti-neurogenic agents in therapy.

Article Abstract

The regulation of the immune environment within the tumor microenvironment has provided new opportunities for cancer treatment. However, an important microenvironment surrounding cancer that is often overlooked despite its significance in cancer progression is the neural environment surrounding the tumor. The release of neurotrophic factors from cancer cells is implicated in cancer growth and metastasis by facilitating the infiltration of nerve cells into the tumor microenvironment. This nerve-tumor interplay can elicit cancer cell proliferation, migration, and invasion in response to neurotransmitters. Moreover, it is possible that cancer cells could establish a network resembling that of neurons, allowing them to communicate with one another through neurotransmitters. The expression levels of players in the neural circuits of cancers could serve as potential biomarkers for cancer aggressiveness. Notably, the upregulation of certain players in the neural circuit has been linked to poor prognosis in specific cancer types such as breast cancer, pancreatic cancer, basal cell carcinoma, and stomach cancer. Targeting these players with inhibitors holds great potential for reducing the morbidity and mortality of these carcinomas. However, the efficacy of anti-neurogenic agents in cancer therapy remains underexplored, and further research is necessary to evaluate their effectiveness as a novel approach for cancer treatment. This review summarizes the current knowledge on the role of players in the neural circuits of cancers and the potential of anti-neurogenic agents for cancer therapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417274PMC
http://dx.doi.org/10.3390/cells12151996DOI Listing

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