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| http://dx.doi.org/10.3389/fped.2023.1198673 | DOI Listing |
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Genetics of intracerebral hemorrhage.
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McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.
Spontaneous intracerebral hemorrhage(ICH) represents a life-threatening form of stroke, marked by its impact on survival and quality of life. ICH can be categorized from monogenic disorders linked to causal germline variants in ICH-related genes to complex sporadic cases, highlighting the interaction among lifestyle factors, environmental influences, and genetic components in determining risk. Among sporadic ICH, the influence of these factors varies across ICH subtypes, evidenced by heritability rates of up to 73% for lobar ICH versus 34% for non-lobar ICH.
View Article and Find Full Text PDFA multi-omics approach to unravel the interaction between heat and drought stress in the holobiont.
Front Plant Sci
December 2024
Department for Sustainable Food Process, Università Cattolica del Sacro Cuore, Piacenza, Italy.
The impact of combined heat and drought stress was investigated in and compared to individual stresses to reveal additive effects and interactions. A combination of plant metabolomics and root and rhizosphere bacterial metabarcoding were used to unravel effects at the plant holobiont level. Hierarchical cluster analysis of metabolomics signatures pointed out two main clusters, one including heat and combined heat and drought, and the second cluster that included the control and drought treatments.
View Article and Find Full Text PDFSuture Suspensionplasty Compared With Ligament Reconstruction and Tendon Interposition for Surgical Treatment of Thumb Carpometacarpal Arthritis.
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November 2024
University of Pittsburgh Medical Center Department of Orthopedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Purpose: Thumb carpometacarpal (CMC) arthritis is the most common arthritis of the hand, with most studies demonstrating little difference in outcomes between various surgical treatment techniques. However, trapeziectomy, followed by ligament reconstruction and tendon interposition (LRTI), remains the technique of choice among hand surgeons in the United States. In 2009, suture suspensionplasty (SS) was first described as a less invasive alternative to LRTI.
View Article and Find Full Text PDFElectrospun composite membranes of ethyl cellulose and MXene (TiCT): Biocompatible platforms for enhanced drug delivery and antibacterial wound healing.
Int J Biol Macromol
December 2024
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Materials Science and Technology, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:
Ethyl cellulose (EC), a degradable cellulose derivative, served as a primary component in membranes fabricated by electrospinning for in vitro drug delivery applications. An effective strategy to enhance drug release was incorporating high-surface-area nanomaterials into polymeric drug carriers, which facilitated drug attachment to both the polymer matrix and additive surfaces, promoting release. MXene (TiCT) demonstrated promising potential in improving tensile mechanical properties, antibacterial activity, and curcumin (Cur) release performance of EC membrane.
View Article and Find Full Text PDFOrganoleptic, physicochemical, phytochemical and pharmacological evaluation of six medicated ghee used for Ayurvedic management of Epilepsy.
J Ayurveda Integr Med
December 2024
Department of Pharmacognosy, Goa College of Pharmacy, Panaji, Goa University, Goa, 403 001, India.
Article Synopsis
- This study explores Ayurvedic formulations, specifically polyherbal medicated ghee (Ghrita), for managing epilepsy by testing their effects on seizure activity in mice.
- Six marketed Ghrita formulations, including Baidyanath Brahmi Ghrita (BBG), were analyzed for their physical, chemical, and pharmacological properties, using systematic testing methods.
- Results indicate that BBG provides the best protection against convulsions induced by pentylene tetrazole (PTZ), showcasing its potential as an effective treatment for epilepsy.
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