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http://dx.doi.org/10.3389/fimmu.2023.1252939 | DOI Listing |
bioRxiv
November 2024
Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.
The general stress response (GSR) protects bacteria from a wide range of stressors. In , GSR activation is coordinated by HWE/HisKA2 family histidine kinases (HKs), which can exhibit non-canonical structure and function. For example, while most light-oxygen-voltage sensor-containing HKs are light activated dimers, the RT-HK has inverted "dark on, light off" signaling logic with a tunable monomer/dimer equilibrium.
View Article and Find Full Text PDFCommun Biol
November 2024
Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, the Australian National University, Canberra, Australian Capital Territory, Australia.
Multidrug-resistant (MDR) Acinetobacter baumannii are of major concern worldwide due to their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective treatment strategy, it is critical to better understand how an A. baumannii MDR bacterium interacts with its mammalian host.
View Article and Find Full Text PDFFront Hum Neurosci
September 2024
Laboratory of Neurogenesis and Neuroplasticity, Department of Physiology, Biophysics and Neuroscience, Centro de Investigacion y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.
The entorhinal cortex (EC) and hippocampal (HC) connectivity is the main source of episodic memory formation and consolidation. The entorhinal-hippocampal (EC-HC) connection is classified as canonically glutamatergic and, more recently, has been characterized as a non-canonical GABAergic connection. Recent evidence shows that both EC and HC receive inputs from dopaminergic, cholinergic, and noradrenergic projections that modulate the mnemonic processes linked to the encoding and consolidation of memories.
View Article and Find Full Text PDFWorld J Gastroenterol
September 2024
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Cancer cell dormancy (CCD) in colorectal cancer (CRC) poses a significant challenge to effective treatment. In CRC, CCD contributes to tumour recurrence, drug resistance, and amplifying the disease's burden. The molecular mechanisms governing CCD and strategies for eliminating dormant cancer cells remain largely unexplored.
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