AI Article Synopsis
- Recent clinical trials for potent complex I inhibitors like IACS-010759 ended unsuccessfully, raising doubts about oxidative phosphorylation inhibitors.
- The analysis of these drugs reveals important lessons regarding their effectiveness, the specific tissues they affect, and potential toxicity issues.
- This situation opens up new avenues for research and development in targeting mitochondria and finding more effective treatments.
Article Abstract
In light of the disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies has been called into question. Consideration of these agents’ potency, tissue selectivity and toxicity demonstrate what lessons can be learned from this failure and where new opportunities lie.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491675 | PMC |
| http://dx.doi.org/10.1038/s41416-023-02394-9 | DOI Listing |
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