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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Paris Brain Institute, PARIS, France.
Background: Over-representation of several health conditions (such as diabetes, hearing loss, etc) have been identified up to 15 years before Alzheimer's Disease (AD) diagnosis through the study of electronic health records [1]. Mechanisms underlying these associations remain elusive. We propose to study the associations between these co-pathologies (proxied by genetic risk scores), and the physiological and clinical evolution of AD patients.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea, Republic of (South).
Background: Numerous studies have demonstrated an association between altered liver function and Alzheimer's disease (AD) or related dementia. Nevertheless, the neuropathological substrates underlying the association remains unclear. Our aim was to investigate the association between liver function markers and the longitudinal changes of in vivo AD pathologies.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Subjective cognitive decline (SCD) may provide an early indicator of Alzheimer's disease. Dyadic SCD, the self/patient's in relation to an informant/loved one's endorsement of SCD, may better reflect underlying Alzheimer's pathology. We related dyadic SCD discrepancies to longitudinal changes of cognitive aging.
View Article and Find Full Text PDFAdvancing precision medicine: the transformative role of artificial intelligence in immunogenomics, radiomics, and pathomics for biomarker discovery and immunotherapy optimization.
Cancer Biol Med
January 2025
Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Artificial intelligence (AI) is significantly advancing precision medicine, particularly in the fields of immunogenomics, radiomics, and pathomics. In immunogenomics, AI can process vast amounts of genomic and multi-omic data to identify biomarkers associated with immunotherapy responses and disease prognosis, thus providing strong support for personalized treatments. In radiomics, AI can analyze high-dimensional features from computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) images to discover imaging biomarkers associated with tumor heterogeneity, treatment response, and disease progression, thereby enabling non-invasive, real-time assessments for personalized therapy.
View Article and Find Full Text PDFRepeated Supera stent fracture following stenting for popliteal artery occlusion: a case report.
J Int Med Res
January 2025
Department of Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea.
The popliteal artery segment is particularly challenging for endovascular treatment. Stents used for treating popliteal artery lesions are usually associated with an increased risk of stent fracture and re-occlusion. The Supera stent is designed to withstand mechanical stress, with a low risk of fracture.
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