AI Article Synopsis
- The paper discusses a method for desymmetrizing cyclohexadienones using a stereoselective intramolecular reaction involving a chiral sulfinamide nucleophile.
- The process uses phase-transfer catalysis to enhance the reaction efficiency.
- The reaction achieved high yields of nitrogen-containing bicyclic compounds, with yields up to 93% and a diastereomeric ratio exceeding 20:1.
Article Abstract
This paper reports the desymmetrization of cyclohexadienones through stereoselective intramolecular aza-Michael addition with a tethered chiral sulfinamide nucleophile. The reaction was facilitated by phase-transfer catalysis and produced various nitrogen-containing bicyclic compounds with a yield of up to 93% and a diastereomeric ratio of up to >20:1.
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| http://dx.doi.org/10.1021/acs.joc.3c01253 | DOI Listing |
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