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Pruritus in atopic dermatitis: a cross-sectional study of adult patients from a tertiary university hospital in São Paulo, Brazil.
An Bras Dermatol
March 2025
Department of Dermatology, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:
Background: Chronic pruritus is the defining symptom of atopic dermatitis (AD). Although AD is common in Latin America, there is little data regarding pruritus intensity, characteristics, and effects on quality of life in this population.
Objective: This cross-sectional study aimed to evaluate pruritus in 91 patients with AD at a tertiary university hospital in São Paulo, Brazil.
Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria.
J Neuroinflammation
March 2025
College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, 430061, China.
Chronic urticaria (CU) arises from a multifaceted interplay of immunological, neurological, and psychological components. Immune dysregulation, mediated through both immunoglobulin E (IgE)-dependent and IgE-independent pathways, plays a pivotal role in CU pathogenesis, involving key effector cells such as mast cells (MCs), basophils, and eosinophils. This dysregulation culminates in the release of histamine, prostaglandins, and other mediators, which precipitate pruritus.
View Article and Find Full Text PDFExploring Immune-Related Biomarkers in Human Itch.
Dermatitis
March 2025
Dr. Phillip Frost Dept of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Coral Gables, FL, USA.
Itch is a debilitating symptom that affects ∼40% of the population and significantly impacts patients' quality of life. The management of chronic itch remains a significant challenge due to the limited availability of reliable biomarkers for assessing its severity. This review aims to investigate the key neuroimmune-related biomarkers involved in the pathophysiology of itch and itch-dependent diseases.
View Article and Find Full Text PDFPredictors for the Efficacy of 4-Week Dupilumab Treatment in Atopic Dermatitis Patients.
J Asthma Allergy
March 2025
Department of Dermatology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, Henan, People's Republic of China.
Background: Atopic dermatitis (AD) is a common inflammatory disease with heterogeneous clinical features. Certain meaningful phenotypes and clinical features may help better classify AD patients for personalized medicine. To our knowledge, no ideal predictors have been found so far.
View Article and Find Full Text PDFEfficacy and Safety of 611 in Chinese Adults with Moderate-to-Severe Atopic Dermatitis: Results from a Phase II Trial.
Dermatol Ther (Heidelb)
March 2025
Department of Dermatology, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China.
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease. 611, a humanized monoclonal antibody, selectively targets the interleukin (IL)-4 receptor alpha, thereby inhibiting the signaling of both interleukin (IL)-4 and IL-13. This phase 2 study aimed to evaluate the efficacy and safety of 611 in Chinese adults with moderate-to-severe AD.
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