AI Article Synopsis
- Blood and lymphatic vasculatures are crucial for regulating physiological activity and maintaining homeostasis and immune responses in the body.
- Inflammation is a protective response to injury that involves altered permeability of blood and lymphatic vessels, leading to new blood (angiogenesis) and lymphatic (lymphangiogenesis) vessel formation.
- The review highlights how these vascular systems interact during inflammation in various organs and explores potential strategies for targeting these systems to manage inflammation in diseases.
Article Abstract
Physiological activity cannot be regulated without the blood and lymphatic vasculatures, which play complementary roles in maintaining the body's homeostasis and immune responses. Inflammation is the body's initial response to pathological injury and is responsible for protecting the body, removing damaged tissues, and restoring and maintaining homeostasis in the body. A growing number of researches have shown that blood and lymphatic vessels play an essential role in a variety of inflammatory diseases. In the inflammatory state, the permeability of blood vessels and lymphatic vessels is altered, and angiogenesis and lymphangiogenesis subsequently occur. The blood vascular and lymphatic vascular systems interact to determine the development or resolution of inflammation. In this review, we discuss the changes that occur in the blood vascular and lymphatic vascular systems of several organs during inflammation, describe the different scenarios of angiogenesis and lymphangiogenesis at different sites of inflammation, and demonstrate the prospect of targeting the blood vasculature and lymphatic vasculature systems to limit the development of inflammation and promote the resolution of inflammation in inflammatory diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408656 | PMC |
| http://dx.doi.org/10.2147/JIR.S414891 | DOI Listing |
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