Multifunctional effects in magnetic nanoparticles for precision medicine: combining magnetic particle thermometry and hyperthermia.

Nanoscale Adv

INRiM, Advanced Materials Metrology and Life Sciences Torino I-10135 Italy

Published: August 2023

An effective combination of magnetic hyperthermia and thermometry is shown to be implementable by using magnetic nanoparticles which behave either as a heat sources or as temperature sensors when excited at two different frequencies. Noninteracting magnetite nanoparticles are modeled as double-well systems and their magnetization is obtained by solving rate equations. Two temperature sensitive properties derived from the cyclic magnetization and exhibiting a linear dependence on temperature are studied and compared for monodisperse and polydisperse nanoparticles. The multifunctional effects enabling the combination of magnetic hyperthermia and thermometry are shown to depend on the interplay among nanoparticle size, intrinsic magnetic properties and driving-field frequency. Magnetic hyperthermia and thermometry can be effectively combined by properly tailoring the magnetic properties of nanoparticles and the driving-field frequencies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408592PMC
http://dx.doi.org/10.1039/d3na00197kDOI Listing

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