Objective: Plant-based natural antioxidants have a wide variety of biological activities with significant therapeutic value. has been used traditionally to treat a variety of ailments in animals and human, but little is defined about its biological or pharmacological effects. Therefore, the objective of the present study was to evaluate phytochemical, antioxidant, antipyretic and anti-inflammatory activities of aqueous-methanolic leaf extract of .
Methods: To investigate the possible impact of aqueous-methanolic leaf extract of on oxidative stress, inflammation, and pyrexia, we used a combined in vitro and in vivo series of experiments on laboratory animals.
Results: Results revealed significant antioxidant potential in 2,2-diphenylpicrylhydrazyl (DPPH) and nitric oxide (NO) scavenging assay, while significant but dose dependent antipyretic potential was documented in typhoid-paratyphoid A and B (TAB) vaccine and prostaglandin E (PGE) induced pyrexia models. Significant anti-inflammatory effects were observed in both acute and chronic inflammatory models of arachidonic acid and formalin. Phytochemical screening and high-performance liquid chromatography (HPLC) analysis of confirmed the presence of mangiferin, quercetin, and isoquercetin. These phytoconstituents likely play a role in the observed biological activities. Our results show that has antioxidant, anti-inflammatory, and antipyretic effects, lending credence to its traditional use and advocating for its utilization as a viable contender in treating oxidative stress-associated ailments.
Conclusion: It is concluded that has various properties in the treatment of various diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408527 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Isolation of Lessertiosides A and B and Other Metabolites from and Their Neuroprotection Activity.
Plants (Basel)
November 2024
Chemistry Department, Cape Peninsula University of Technology, Symphony Rd. Bellville, Cape Town 7535, South Africa.
(synonym ) is an important South African medicinal plant used traditionally to treat different human pathologies and is considered an adaptogenic plant. This study sought to isolate compounds from the plant and determine their protective potentials using SH-SY5Y cells and MPP (1-methyl-4-phenylpyridinium) to mimic Parkinson's disease. The phytochemical analysis of a 70% aqueous methanolic extract of leaves resulted in the isolation and identification of 11 pure compounds (-), among which compounds and were identified as new metabolites.
View Article and Find Full Text PDFIdentification of different extracts and phytoconstituents of for their anti-anxiety effects based on pharmacognostic, toxicological, and pharmacological strategies.
Toxicol Rep
December 2024
Department of Pharmacology, Amity Institute of Pharmacy, Amity University Haryana, Gurugram, Haryana 122413, India.
Background: Psychiatric disorders like depression and anxiety are global challenges, exacerbated by the limitations of synthetic medications, including addiction and toxic side effects.
Methods: This study meticulously investigated the pharmacognostic, phytochemical, toxicological, and pharmacological properties of Callistemon viminalis Cheel. Toxicological assessments, including hemocompatibility assays, LD studies, FOB analysis, biochemical parameters, and structural integrity of vital organs, were conducted on aqueous, methanolic, chloroform, and petroleum ether extracts of leaves and stems.
Insecticidal activity of leaf extracts on cowpea bruchid (Coleoptera: Chrysomelidae).
Heliyon
July 2024
Department of Biological Sciences, Faculty of Science, University of Ngaoundere, Cameroon.
The protection of foodstuffs against insect pests constitutes a serious problem across the world. Synthetic chemical insecticides are the most widely used method for grain protection. Unfortunately, the harmful effects of these insecticides on human health and environment have increased the interest of researchers for botanical insecticides which are recognized as eco-friendly products.
View Article and Find Full Text PDFEfficacy and mechanism of gel for musculoskeletal injuries.
Am J Transl Res
May 2024
Department of Pathobiology and Biomedical Sciences, MNS University of Agriculture Multan 60000, Pakistan.
Objective: Formulate a gel and test its scientific efficacy for treating musculoskeletal ailments with or without phonophoresis.
Methods: Gel was made from leaf extract (30:70 aqueous-methanolic). A pragmatic, community-based, double-blinded randomized clinical study (IRCT20230202057310N1) was undertaken on 380 pre-diagnosed individuals with 1st and 2nd-grade musculoskeletal injuries, divided into four parallel groups (n = 95 per group): Group I got phonophoresis-applied 10% gel.
Antimalarial activity of MJ Roem aqueous methanolic leaf extract and its antioxidant and phytochemical properties.
J Tradit Complement Med
November 2023
Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, 751023, Odisha, India.
Background And Aim: Malaria is a global health issue causing substantial morbidity and mortality. Screening of various traditionally important medicinal plants is a key source for the discovery of new antimalarials. We evaluated the antimalarial and antioxidant activities, and performed detailed phytochemical analyses of MJ Roem aqueous methanolic leaf extract (MLE).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!