AI Article Synopsis
- STIs, particularly HPV, are significant health issues that can lead to cervical abnormalities and cancer.
- The study focused on 190 women in northeastern Iran to investigate the link between STIs and cervical cell changes.
- Findings showed that while many women had STIs, a majority maintained normal cervical cytology, highlighting the need for comprehensive STI and HPV testing alongside traditional cytology for effective cervical cancer screening.
Article Abstract
Background: Sexually transmitted infections (STIs) are one of the world's most severe health challenges. The existence of STIs such as human papillomavirus (HPV) might cause cervical cell changes leading to cervical cancer.
Objective: This study aims to assess the association of STIs with cervical cytological abnormalities and genital warts among women in northeastern Iran.
Materials And Methods: This cross-sectional study was carried out on 190 women referred to the central laboratory of Academic Center for Education, Culture, and Research, Mashhad, Iran from March to July 2022. The presence of genital infections caused by , , , and Herpes simplex viruses (1 and 2) were assessed using the real-time polymerase chain reaction method. HPV genital infection was detected based on the principles of reverse hybridization, and cellular changes in the cervix were examined by the liquid-based cytology technique.
Results: The mean age of participants was 35.33 8.9 yr. 34 different HPV genotypes were detected in all HPV-positive cases, and the most common genotype was low-risk HPV6. No significant association was found between STIs and cervical cytology abnormalities. The prevalence rates of sexually transmitted pathogens among HPV-positive and HPV-negative individuals were 10.9 and 1.6%, respectively. The frequency of genital warts was significantly higher in cases with multiple infections of high- and low-risk HPV genotypes.
Conclusion: High percentages of the participants with non-HPV STIs and HPV infection had normal cervical cytology. It is advised to use STIs and HPV diagnostic tests along with cytology examinations for cervical cancer screening.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407913 | PMC |
| http://dx.doi.org/10.18502/ijrm.v21i6.13636 | DOI Listing |
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